6,836 results found
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Towards novel herbicide modes of action by inhibiting lysine biosynthesis in plants

    Tatiana P Soares da Costa et al.
    Proof-of-principle for a new herbicide mode of action through the identification of novel inhibitors of lysine biosynthesis with in planta efficacy.
    1. Neuroscience

    The role of P2Y12 in the kinetics of microglial self-renewal and maturation in the adult visual cortex in vivo

    Monique S Mendes et al.
    Adult microglia are born by the division of single surviving microglia that rapidly acquire mature morphologies and functions in order to perform their physiological roles in the brain.
    1. Neuroscience

    Transcriptomic encoding of sensorimotor transformation in the midbrain

    Zhiyong Xie et al.
    Single-cell RNA-sequencing and neural circuitry analyses reveal that sensorimotor transformation of different behaviors which are performed by separate circuit modules in the superior colliculus are molecularly defined by distinct transcriptomic codes of specific neuron subtypes.
    1. Cell Biology
    2. Computational and Systems Biology

    Quantitative live-cell imaging and computational modeling shed new light on endogenous WNT/CTNNB1 signaling dynamics

    Saskia MA de Man et al.
    Genome editing, advanced live-cell microscopy, and computational modeling were combined to measure WNT/CTNNB1 signaling parameters at the single molecule level, revealing critical regulatory nodes in this important signal transduction pathway.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural intermediates observed only in intact Escherichia coli indicate a mechanism for TonB-dependent transport

    Thushani D Nilaweera et al.
    Pulse electron paramagnetic resonance on intact Escherichia coli reveals a substrate-induced structural transition in BtuB, the vitamin B12 transporter, which is not seen in reconstituted membranes and indicates a mechanism of transport.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Cdc4 phospho-degrons allow differential regulation of Ame1CENP-U protein stability across the cell cycle

    Miriam Böhm et al.
    The cell cycle machinery regulates the assembly of the multi-protein kinetochore complex by targeting excess subunits for degradation via the proteasome.
    1. Medicine

    Risk of motor vehicle collisions after methadone use

    Ya-Hui Yang et al.
    Methadone maintenance treatment (MMT) can alleviate opioid dependence, however, drivers receiving MMT were at high risk of motor vehicle collisions in the present study, particularly the first 90 days of MMT.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Highly contiguous assemblies of 101 drosophilid genomes

    Bernard Y Kim et al.
    One hundred one high-quality drosophilid genomes are released, along with low-cost assembly workflows, as an open community resource for studying genetics, ecology, and evolution in this important model system.
    1. Immunology and Inflammation

    Latent gammaherpesvirus exacerbates arthritis through modification of age-associated B cells

    Isobel C Mouat et al.
    Latent gammaherpesvirus infection predisposes mice to develop more severe disease following induction of arthritis by elevating pathogenic interferon-gamma-expressing age-associated B cells.
    1. Neuroscience

    A role for glial fibrillary acidic protein (GFAP)-expressing cells in the regulation of gonadotropin-releasing hormone (GnRH) but not arcuate kisspeptin neuron output in male mice

    Charlotte Vanacker et al.
    Astrocyte signaling can activate the firing of gonadotropin-releasing hormone neurons and stimulate hormone release.

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