720 results found
    1. Cell Biology

    G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion

    Vladimir Purvanov et al.
    siRNA knockdown experiments reveal in detail the signaling pathway that controls cytoskeletal function during cell-in-cell invasion.
    1. Structural Biology and Molecular Biophysics

    Gating mechanisms during actin filament elongation by formins

    Fikret Aydin et al.
    Formins slow elongation of actin filament by either sterically blocking the addition of actin subunits or flattening the helical twist of the filament end.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Modulation of formin processivity by profilin and mechanical tension

    Luyan Cao et al.
    Profilin helps to maintain formin at the growing barbed end of an actin filament, while piconewton mechanical tension drastically enhances formin dissociation from the barbed end.
    1. Cell Biology

    Cytoplasmic translocation of the retinoblastoma protein disrupts sarcomeric organization

    Keigo Araki et al.
    TNF-α treatment induces phosphorylation and cytoplasmic translocation of the retinoblastoma protein, which regulates cytoskeletal organization in skeletal muscle cells.
    1. Cell Biology

    A disassembly-driven mechanism explains F-actin-mediated chromosome transport in starfish oocytes

    Philippe Bun et al.
    On entry to meiosis, chromosomes scattered in the large oocyte nucleus of starfish are collected by an F-actin network, which contracts by an unexpected, myosin-independent mechanism based on local assembly and global disassembly of actin filaments.
    1. Neuroscience

    The CNS connectome of a tadpole larva of Ciona intestinalis (L.) highlights sidedness in the brain of a chordate sibling

    Kerrianne Ryan et al.
    Serial-section EM analysis uncovers the CNS connectome of a Ciona larva, the second of any entire nervous system, and exposes left-right asymmetries in its synaptic circuits.
    1. Computational and Systems Biology

    Active contraction of microtubule networks

    Peter J Foster et al.
    Microtubule networks in frog egg extracts can spontaneously contract in a manner that can be quantitatively described by an active fluid model.
    1. Cell Biology

    Generation of stress fibers through myosin-driven reorganization of the actin cortex

    Jaakko I Lehtimäki et al.
    Live-cell microscopy studies revealed that stress fibers can be generated de novo from the actin cortex without the involvement of stress fiber precursors.
    1. Cell Biology
    2. Developmental Biology

    CCN1 interlinks integrin and hippo pathway to autoregulate tip cell activity

    Myo-Hyeon Park et al.
    Cyr61 autoregulating tip cell activity by interlinking integrin and Hippo pathway and targeting Cyr61 provides promising therapeutic approach for the treatment of pathological angiogenesis, including tumour angiogenesis.
    1. Cell Biology

    Reconstitution of self-organizing protein gradients as spatial cues in cell-free systems

    Katja Zieske, Petra Schwille
    A minimal cell-like system with defined geometry has been used to investigate the establishment and spatial control of a protein gradient that positions the bacterial cell division machinery.

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