The ES6S region of the small subunit ribosome makes a place for the threading and secondary structure unwinding of mRNA, which regulates genome-wide translation.
Qiushuang Wu, Santiago Gerardo Medina ... Ariel Alejandro Bazzini
Genomic-profiles and reporters reveal that the three-nucleotide ‘words’ read by the ribosome, codons, have a strong effect on mRNA stability, impacting the homeostatic mRNA and protein levels in human cells.
Rachael Di Santo, Soufiane Aboulhouda, David E Weinberg
The unspliced HAC1 mRNA does not give rise to detectable protein in budding yeast, despite its cytoplasmic localization, due to a two-part post-transcriptional silencing mechanism.
Michele Felletti, Cédric Romilly ... Kristina Jonas
Specific amino acids in the N-terminus of the replication initiator protein DnaA inhibit translation elongation upon carbon starvation, illustrating that the identity of the N-terminal amino acids of a protein can modulate protein synthesis yield under changing conditions.
Anthony J Veltri, Karole N D'Orazio ... Rachel Green
Genetic screens and functional assays utilizing reporter mRNAs triggering NGD or COMD provide a basis for understanding the unique contributions of each pathway to translation-coupled mRNA decay and contextualizes their effects in the larger cellular process of translation surveillance.
Masatoshi Hara, Boryana Petrova, Terry L Orr-Weaver
The kinase that controls maternal mRNA translation is regulated by phosphorylation of its activating subunit to restrict kinase activity to the developmental window between meiosis completion and early embryogenesis.
Mitochondria can tune the protein synthesis of nuclear-encoded proteins through condition-dependent mRNA localization that is regulated by translation elongation and the geometric constraints of the cell.
Mary K Thompson, Maria F Rojas-Duran ... Wendy V Gilbert
Asc1/RACK1 promotes the translation of mRNAs associated with the translational closed loop complex, which have short open reading frames and encode proteins required for core metabolic processes.
The RNA-binding protein, Zfp36, which is critical for resolving inflammation, inhibits the production of proinflammatory cytokines via modulation of the cytoplasmic poly(A)-binding protein.
