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  1. January 2015

    Episode 17: January 2015

    In this episode we hear about controlling sperm by optogenetics, hibernation, body clocks, enzyme structure, and a way to overcome stress-induced infertility.
    1. Genetics and Genomics
    2. Neuroscience

    Taar1 gene variants have a causal role in methamphetamine intake and response and interact with Oprm1

    Alexandra M Stafford et al.
    The trace amine-associated receptor 1 gene has a causal role in methamphetamine intake and thermal response, and interacts with the mu-opioid receptor gene in its methamphetamine addiction-related effects.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Absolute quantification of cohesin, CTCF and their regulators in human cells

    Johann Holzmann et al.
    Absolute quantification of cohesin, CTCF, NIPBL, WAPL and sororin in HeLa cells implies that some genomic cohesin and CTCF enrichment sites are unoccupied at any one time.
    1. Human Biology and Medicine
    2. Structural Biology and Molecular Biophysics

    A calcium transport mechanism for atrial fibrillation in Tbx5-mutant mice

    Wenli Dai et al.
    TBX5-loss associated cardiomyocyte ectopy and atrial fibrillation is prevented by augmentation of SERCA2 activity, establishing a mechanism underlying the genetic basis for a Ca2+-dependent pathway for AF risk.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency

    Maxim Greenberg et al.
    Three-dimensional chromatin architecture facilitates a promoter switch in order to ensure maintained expression of a gene involved in growth during embryonic stem cell differentiation.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

    Nealia CM House et al.
    Despite differing by only one amino acid in the C-terminal tail, copy 1 of yeast histone 2A has a repair-specific role not shared by copy 2.
    1. Cell Biology
    2. Neuroscience

    Neurotrophins induce fission of mitochondria along embryonic sensory axons

    Lorena Armijo-Weingart et al.
    Induction of the fission of mitochondria-populating sensory axons is shown to be a novel biological action of neurotrophins.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Demographic reconstruction from ancient DNA supports rapid extinction of the great auk

    Jessica E Thomas et al.
    Reconstruction of great auk population dynamics suggests that hunting pressure alone could have been responsible for their extinction, demonstrating that even abundant, widespread species can be vulnerable to intense exploitation.
    1. Cell Biology

    Brain-specific Drp1 regulates postsynaptic endocytosis and dendrite formation independently of mitochondrial division

    Kie Itoh et al.
    Genetic and cell biological analyses reveal a new role of Drp1 in postsynaptic endocytosis during brain development beyond mitochondrial division GTPase.
    1. Chromosomes and Gene Expression
    2. Human Biology and Medicine

    Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair

    Natasa Savic et al.
    Linking the DNA repair template to the Cas9 ribonucleoprotein complex enhances homology-directed repair of the induced DNA double strand break.