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    1. Immunology and Inflammation

    Diversity and functional specialization of oyster immune cells uncovered by integrative single cell level investigations

    Sébastien de La Forest Divonne, Juliette Pouzadoux ... Emmanuel Vignal
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Formation of a giant unilocular vacuole via macropinocytosis-like process confers anoikis resistance

    Jeongsik Kim, Dahyun Kim ... Dae-Sik Lim
    Formation of a giant unilocular vacuole through a macropinocytosis-like process in cells with disrupted actin cytoskeleton promotes resistance to anoikis.
    1. Cancer Biology

    A multi-gene predictive model for the radiation sensitivity of nasopharyngeal carcinoma based on machine learning

    Kailai Li, Junyi Liang ... Hui Meng
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology

    Negative regulation of APC/C activation by MAPK-mediated attenuation of Cdc20Slp1 under stress

    Li Sun, Xuejin Chen ... Quan-wen Jin
    Inhibitory effect on the activation of anaphase-promoting complex/cyclosome (APC/C) by MAPK Pmk1.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    An arms race between 5’ppp-RNA virus and its alternative recognition receptor MDA5 in RIG-I-lost teleost fish

    Shang Geng, Xing Lv ... Tianjun Xu
    5’ppp-RNA, a traditional ligand for RIG-I, can be recognized by MDA5 in species such as Miichthys miiuy and Gallus gallus that lack RIG-I.
    1. Microbiology and Infectious Disease
    2. Epidemiology and Global Health

    Protection afforded by post-infection SARS-CoV-2 vaccine doses: a cohort study in Shanghai

    Bo Zheng, Bronner Gonçalves ... Caoyi Xue
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Convincing
    1. Cell Biology
    2. Neuroscience

    Iron-sulfur cluster loss in mitochondrial CISD1 mediates PINK1 loss-of-function phenotypes

    Sara Bitar, Timo Baumann ... Axel Methner
    PINK1 deficiency in Parkinson's disease models causes toxic oxidized and iron-depleted CISD1 yet CISD1 removal benefits PINK1 mutant Drosophila indicating its potential as a therapeutic target for mitochondrial dysfunction and neurodegeneration.
    1. Developmental Biology
    2. Genetics and Genomics

    PRMT1-SFPQ regulates intron retention to control matrix gene expression during craniofacial development

    Julia Raulino Lima, Nicha Ungvijanpunya ... Jian Xu
    Not revised
    Reviewed Preprint v1
    • Important
    • Incomplete
    1. Cell Biology

    TRIP13 localizes to synapsed chromosomes and functions as a dosage-sensitive regulator of meiosis

    Jessica Y Chotiner, N Adrian Leu ... P Jeremy Wang
    Mouse TRIP13 localizes to synapsed chromosomal axes and thus exhibits mutually exclusive localization with HORMAD1/HORMAD2, providing a cell biological explanation for dissociation of HORMAD1/2 from chromosomal axes upon synapsis.
    1. Developmental Biology

    Redistribution of fragmented mitochondria ensure symmetric organelle partitioning and faithful chromosome segregation in mitotic mouse zygotes

    Haruna Gekko, Ruri Nomura ... Takuya Wakai
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
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