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Page 3 of 211
    1. Neuroscience

    Unveiling the sensory and interneuronal pathways of the neuroendocrine connectome in Drosophila

    Sebastian Hückesfeld et al.
    Core of a neuroendocrine synaptic network consists of a parallel set of interneurons that target distinct combinations of neuroendocrine outputs, thus enabling variability and flexibility in selection of physiological activity.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A subcellular map of the human kinome

    Haitao Zhang et al.
    An immunofluorescent analysis of 465 protein kinases revealed a substantial role of liquid-liquid phase separation in kinase localization and identified new kinase localizations to mitochondria and other organelles.
    1. Neuroscience

    Cellular, circuit and transcriptional framework for modulation of itch in the central amygdala

    Vijay K Samineni et al.
    Circuit and transcriptional analysis shows that genetically defined central amygdala neurons and their projections to the ventral periaqueductal gray mediate behavioral and affective responses to pruritus.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Translation inhibitory elements from Hoxa3 and Hoxa11 mRNAs use uORFs for translation inhibition

    Fatima Alghoul et al.
    Hoxa3 and Hoxa11 translation inhibitory elements block cap-dependent translation by using upstream open reading frames with distinct modes of action.
    1. Neuroscience

    Somatostatin-expressing parafacial neurons are CO2/H+ sensitive and regulate baseline breathing

    Colin M Cleary et al.
    Cellular and chemogenetic approaches identify a novel mode of chemotransduction involving regulation of basal breathing by CO2/H+-dependent disinhibition.
    1. Genetics and Genomics
    2. Neuroscience

    Traumatic injury compromises nucleocytoplasmic transport and leads to TDP-43 pathology

    Eric N Anderson et al.
    Traumatic injury leads to functional defects in nucleocytoplasmic transport and TDP-43 pathology in multiple model systems.
    1. Ecology
    2. Microbiology and Infectious Disease

    A novel ATP dependent dimethylsulfoniopropionate lyase in bacteria that releases dimethyl sulfide and acryloyl-CoA

    Chun-Yang Li et al.
    A novel dimethylsulfoniopropionate lyase was identified, which catalyzes dimethyl sulfide releasing by a new mechanism and is found in several bacterial lineages, revealing its important roles in global sulfur cycling.
    1. Neuroscience

    Local circuit allowing hypothalamic control of hippocampal area CA2 activity and consequences for CA1

    Vincent Robert et al.
    Input conveying social novelty information from the hypothalamus controls hippocampal activity by recruiting a novel inhibitory circuit in hippocampal area CA2.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    In vitro proteasome processing of neo-splicetopes does not predict their presentation in vivo

    Gerald Willimsky et al.
    Analysis of neo-splicetope-specific T cell responses strongly questions the idea that in vitro proteasome-catalyzed peptide splicing reaction simulates the in vivo situation with the same high fidelity as the in vitro generation of non-spliced epitopes.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Downregulation of glial genes involved in synaptic function mitigates Huntington's disease pathogenesis

    Tarik Seref Onur et al.
    Cross-species transcriptomic analysis and high-throughput behavioral assays in a Drosophila model of Huntington's disease show that downregulation of glial genes involved in synaptic function compensates for disease-related excitotoxicity.