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Page 4 of 218
    1. Developmental Biology

    Pak1 and PP2A antagonize aPKC function to support cortical tension induced by the Crumbs-Yurt complex

    Cornelia Biehler et al.
    Cell biology analyses in Drosophila epithelial tissues reveal novel mechanisms connecting epithelial polarity proteins with Myosin-dependent cell contractility.
    1. Microbiology and Infectious Disease

    A novel mechanosensitive channel controls osmoregulation, differentiation, and infectivity in Trypanosoma cruzi

    Noopur Dave et al.
    Structurally divergent bacterial-like mechanosensitive channels control multiple cellular functions in protozoan parasites.
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    A fusion peptide in preS1 and the human protein disulfide isomerase ERp57 are involved in hepatitis B virus membrane fusion process

    Jimena Pérez-Vargas et al.
    The mechanism triggering HBV membrane fusion involves ERp57, a cellular protein disulfide isomerase, and ultimately leads to the exposition of a fusion peptide that was identified in the pre-S1 determinant.
    1. Cancer Biology

    Acid-base transporters and pH dynamics in human breast carcinomas predict proliferative activity, metastasis, and survival

    Nicolai J Toft et al.
    Cellular acidity, capacity for net acid extrusion, and expression of acid-base transporters in human breast carcinomas independently predict variation in proliferative activity, lymph node metastasis, and patient survival.
    1. Cancer Biology
    2. Cell Biology

    Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response

    Kerrie-Ann McMahon et al.
    Cavin3 associates with BRCA1 upon disassembly of caveolae in response to mechanical and non-mechanical stressors to influence DNA repair and apoptosis.
    1. Neuroscience

    Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts

    Jasbir Singh Dalal et al.
    Tsc1 mutation in cerebellar Purkinje cells leads to downregulation of synapse genes that are targets of the Fragile X Mental Retardation Protein.
    1. Cell Biology

    Unique integrated stress response sensors regulate cancer cell susceptibility when Hsp70 activity is compromised

    Sara Sannino et al.
    Unique integrate stress response sensors differentially trigger pro-survival versus pro-apoptotic responses in cells confronted with Hsp70 inhibitor-associated proteotoxic challenges.
    1. Neuroscience

    Stability of neocortical synapses across sleep and wake states during the critical period in rats

    Brian A Cary, Gina G Turrigiano
    Sleep and wake states are not sufficient to drive changes in neocortical synaptic strengths.
    1. Microbiology and Infectious Disease

    Smartphone screen testing, a novel pre-diagnostic method to identify SARS-CoV-2 infectious individuals

    Rodrigo M Young et al.
    PCR testing for SARS-CoV-2 from samples taken from smartphone screens, Phone Screen Testing, provides a sensitive, cost-effective, simple, and non-invasive new method that could boost COVID-19 mass test screening.
    1. Cell Biology
    2. Physics of Living Systems

    Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells

    Saurabh Kulkarni et al.
    Embryonic and mechanical manipulations of Xenopus multiciliated epithelium reveals that cell non-autonomous tensile forces generated by embryonic elongation calibrate cilia number in multiciliated cells via a mechanosensitive ion channel, Piezo1.