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    1. Developmental Biology

    Endothelial EphB4 maintains vascular integrity and transport function in adult heart

    Guillermo Luxán et al.
    EphB4 maintains critical functional properties of the adult cardiac vasculature, namely mechanical resistance and fatty acid transport capability, and thereby prevents dilated cardiomyopathy-like defects.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Transcriptional adaptation in Caenorhabditis elegans

    Vahan Serobyan et al.
    Genes implicated in mutant mRNA decay and small RNA maturation and transport into the nucleus are required for transcriptional adaptation in C. elegans.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Translational regulation of protrusion-localized RNAs involves silencing and clustering after transport

    Konstadinos Moissoglu et al.
    RNAs enriched at cell protrusions are translated regardless of their location in the cytoplasm but are dynamically repressed in retracting protrusions and incorporated into heterogeneous RNA clusters.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences

    Raeann Goering et al.
    The molecular determinants for neuronal subcellular RNA transport by FMRP are defined, with interactions between RNA G-quadruplexes and the RGG domain of FMRP being of critical importance.
    1. Plant Biology

    Temperature-dependent fasciation mutants provide a link between mitochondrial RNA processing and lateral root morphogenesis

    Kurataka Otsuka et al.
    Temperature-dependent fasciation mutants of Arabidopsis unexpectedly connect mitochondrial RNA processing to the control of cell proliferation during lateral root morphogenesis via electron transport chain activity and reactive oxygen species production.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The translation elongation factor eEF1A1 couples transcription to translation during heat shock response

    Maria Vera et al.
    Eukaryotic translation elongation factor 1A1 controls the process of heat shock response, from transcriptional activation of the HSP70 gene, to HSP70 mRNA stabilization, nuclear export, and translation.
    1. Cell Biology

    Competition between kinesin-1 and myosin-V defines Drosophila posterior determination

    Wen Lu et al.
    Posterior determination of Drosophila oocyte is defined by competition between kinesin-1 removing posterior determinants from the cortex and myosin-V anchoring them.
    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    The long non-coding RNA Cerox1 is a post transcriptional regulator of mitochondrial complex I catalytic activity

    Tamara M Sirey et al.
    Mitochondrial energy metabolism is post-transcriptionally regulated through an interplay between long and short non-coding RNAs.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Molecular determinants of large cargo transport into the nucleus

    Giulia Paci et al.
    Efficient nuclear transport of very large biomolecules, relevant for viral transport, scales non-linearly with size and its kinetics can be explained by a simple two-parameter energetic model.
    1. Cancer Biology

    Flura-seq identifies organ-specific metabolic adaptations during early metastatic colonization

    Harihar Basnet et al.
    Development and application of highly sensitive in situ transcriptomics method, Flura-seq, in identifying dynamic organ-specific transcriptomes in early stage breast cancer metastasis have been described.