1,249 results found
    1. Neuroscience

    Output variability across animals and levels in a motor system

    Angela Wenning et al.
    Population output variability in a motor control system varies across levels (CPG, motor neurons, muscles) and can be ascribed to life history differences among animals and in some cases to differences between bilaterally homologous elements.
    1. Immunology and Inflammation

    High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors

    Antoine Marçais et al.
    Chronic engagement of Natural killer cell inhibitory receptors by MHC-I molecules maintains a high activity of the mTOR pathway allowing subsequent amplification of signaling through activating receptors upon acute stimulation.
    1. Neuroscience

    Lognormal firing rate distribution reveals prominent fluctuation–driven regime in spinal motor networks

    Peter C Petersen, Rune W Berg
    Neuronal participation in generation of motor patterns in the spinal circuits is lognormal, which is an indication of a rich diversity of activity within the mean-driven as well as the fluctuation-driven regimes.
    1. Neuroscience

    Motor control of Drosophila feeding behavior

    Olivia Schwarz et al.
    The neuroanatomical and functional analysis of genetically-identified motoneurons controlling all major steps of Drosophila proboscis extension provides new insights into the architecture of a motor circuitry controlling a reaching-like behavior.
    1. Neuroscience

    Feedforward motor information enhances somatosensory responses and sharpens angular tuning of rat S1 barrel cortex neurons

    Mohamed Khateb et al.
    Primary motor cortex afferents supra-linearly amplify the responses and sharpen angular tuning of neurons in the S1 barrel cortex.
    1. Human Biology and Medicine
    2. Neuroscience

    Neural population dynamics in human motor cortex during movements in people with ALS

    Chethan Pandarinath et al.
    Neural ensemble activity in the human motor cortex contains dynamical structure that is independent of movement parameters and is not well-explained by current models.
    1. Neuroscience

    The critical role of membralin in postnatal motor neuron survival and disease

    Bo Yang et al.
    Membralin mutant mice manifest a severe and early-onset motor neuron disease with defects in endoplasmic reticulum-associated protein degradation.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    The Rab6-regulated KIF1C kinesin motor domain contributes to Golgi organization

    Peter L Lee et al.
    Rab6A binds directly to both the C-terminus and the N-terminal motor domain of the kinesin KIF1C to regulate vesicle motility and Golgi organization.
    1. Computational and Systems Biology

    Distributed task-specific processing of somatosensory feedback for voluntary motor control

    Mohsen Omrani et al.
    Somatosensory feedback is transmitted to many sensory and motor cortical regions within 25 milliseconds and ongoing behavioural tasks alter the spatiotemporal pattern of this perturbation-related activity, supporting rapid motor responses to attain behavioural goals.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

    Stephen R Daley et al.
    A single point mutation in a Ras activator leads to aberrant constitutive mTOR signaling in peripheral T cells that consequently accumulate as abnormal T helper cells and stimulate the production of autoantibodies by B cells.

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