380 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding

    Kanokwan Champasa et al.
    Analysis of an essential motif in Mcm4 provides insights into replicative helicase double-hexamer formation and the first step requiring this intermediate during replication initiation.
    1. Genetics and Genomics

    Insulin-like peptides and the mTOR-TFEB pathway protect Caenorhabditis elegans hermaphrodites from mating-induced death

    Cheng Shi et al.
    Hermaphroditic Caenorhabditis elegans slow the onset of mating-induced death through self-sperm-regulated insulin-like gene expression, which regulates the activity of the IIS/FOXO pathway, mTOR signaling, and the TFEB/HLH-30 transcription factor.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Aging: A new defense in the battle of the sexes

    George L Sutphin
    Young Caenorhabditis elegans hermaphrodites use their own sperm to protect against the negative consequences of mating.
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    1. Biochemistry and Chemical Biology
    2. Genetics and Genomics

    A tRNA modification balances carbon and nitrogen metabolism by regulating phosphate homeostasis

    Ritu Gupta et al.
    The role of an amino acid-dependent tRNA modification as a nutrient sensor and regulator of metabolic homeostasis has been discovered.
    1. Cell Biology

    A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome

    Jérémy Magescas et al.
    The microtubule organizing potential of the centrosome is inactivated in a stepwise process through phosphatase activity and mechanical disruption to remove an aging matrix of proteins.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

    Amal Alex et al.
    An electroporation-based method allows the direct delivery of recombinant proteins into mammalian cells for in vivo functional studies.
    1. Cell Biology

    In vivo identification of GTPase interactors by mitochondrial relocalization and proximity biotinylation

    Alison K Gillingham et al.
    Relocation of Rab, Ras and Rho family GTPases to the surface of mitochondria enables efficient identification of their effectors, exchange factors and GAPs by proximity biotinylation.
    1. Developmental Biology

    Fetal and trophoblast PI3K p110α have distinct roles in regulating resource supply to the growing fetus in mice

    Jorge López-Tello et al.
    Fetus and trophoblast interplay to regulate fetal nutrient supply and, ultimately, affect healthy growth.

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