404 results found
  1. Redesigning an online scientific journal from the article up I: Early designs

    Our approach to redesigning a better journal reading experience, starting with the Research Article.
  2. January 2015

    Episode 17: January 2015

    In this episode we hear about controlling sperm by optogenetics, hibernation, body clocks, enzyme structure, and a way to overcome stress-induced infertility.
    1. Cancer Biology

    Mice deficient of Myc super-enhancer region reveal differential control mechanism between normal and pathological growth

    Kashyap Dave et al.
    A tumor-specific regulatory region has been identified upstream of the Myc oncogene.
    1. Cell Biology
    2. Developmental Biology

    Thrombospondin-4 controls matrix assembly during development and repair of myotendinous junctions

    Arul Subramanian, Thomas F Schilling
    Functional attachments between muscles and tendons require pentameric Thrombospondin-4, revealing novel roles both as an integrin ligand and extracellular matrix scaffold.
    1. Neuroscience

    Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone

    Elizabeth A Gould et al.
    Mild myelin disruption leads to early axonal pathology, a novel pathological response in neural stem cells, regionally increased oligodendrocytes and altered behavior.
    1. Cell Biology
    2. Immunology and Inflammation

    Autophagy regulates inflammatory programmed cell death via turnover of RHIM-domain proteins

    Junghyun Lim et al.
    Autophagy is critical for the turnover of inflammatory signaling complexes containing RHIM-domain proteins.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Kinesin Kip2 enhances microtubule growth in vitro through length-dependent feedback on polymerization and catastrophe

    Anneke Hibbel et al.
    The budding yeast kinesin Kip2 is a polymerase that uses its processive motility in a positive feedback loop to promote microtubule growth.
    1. Neuroscience

    Signal integration at spherical bushy cells enhances representation of temporal structure but limits its range

    Christian Keine et al.
    Inhibition reduces the neuronal representation of acoustic signals to enhance temporal precision in the auditory brainstem.
    1. Neuroscience

    Node of Ranvier length as a potential regulator of myelinated axon conduction speed

    I Lorena Arancibia-Cárcamo et al.
    Node of Ranvier length is similar at successive nodes along single myelinated CNS axons, but differs between axons, and could potentially be tuned to adjust the conduction velocity of each axon.
    1. Cell Biology
    2. Human Biology and Medicine

    Intracellular sphingosine releases calcium from lysosomes

    Doris Höglinger et al.
    Sphingosine acts as a lipid messenger molecule in intracellular signaling networks that are relevant to lysosomal function and Niemann-Pick disease.

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