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The microtubule polymerase Stu2 promotes oligomerization of the γ-TuSC for cytoplasmic microtubule nucleation
Judith Gunzelmann et al.
Biochemical and genetic approaches show that the XMAP215 homolog Stu2 directly interacts with the small gamma-tubulin complex and its recruitment factor Spc72 to instigate functions in cytoplasmic microtubule organization.
Biochemistry and Chemical Biology
Intracellular cholesterol trafficking is dependent upon NPC2 interaction with Lysobisphosphatidic Acid
Leslie A McCauliff et al.
Atg9 antagonizes TOR signaling to regulate intestinal cell growth and epithelial homeostasis in
Jung-Kun Wen et al.
Atg9 inhibits TOR signaling to regulate cell growth and tissue homeostasis in
Cellular hallmarks reveal restricted aerobic metabolism at thermal limits
Aitana Neves et al.
Cellular hallmarks of thermal limits are evolutionarily conserved in nematodes, and changes in surface to volume ratio reflect restricted aerobic metabolism at these limits.
YOD1/TRAF6 association balances p62-dependent IL-1 signaling to NF-κB
Gisela Schimmack et al.
The deubiquitinating enzyme YOD1 binds to the E3 ligase TRAF6 to counteract p62/sequestosome1 mediated pro-inflammatory NF-κB signaling in response to interleukin-1.
Chromosomes and Gene Expression
Long non-coding RNA produced by RNA polymerase V determines boundaries of heterochromatin
Gudrun Böhmdorfer et al.
Genome-wide identification of long non-coding RNAs produced by RNA Polymerase V identifies their role in heterochromatin maintenance on the boundaries of repressed regions.
Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABA
receptors on dendritic spines
Sonia Afroz et al.
receptors that emerge at puberty trigger adolescent synaptic pruning; pruning is prevented and cognition is impaired if the receptors are absent.
Physics of Living Systems
A first order phase transition mechanism underlies protein aggregation in mammalian cells
Arjun Narayanan et al.
Quantitative single molecule and super resolution imaging in mammalian cells reveal a population of precursor aggregates describable by first order phase transition theory.
Structural Biology and Molecular Biophysics
Cryo-EM structures of the human glutamine transporter SLC1A5 (ASCT2) in the outward-facing conformation
Xiaodi Yu et al.
May roundup of eLife papers in the news
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