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    1. Human Biology and Medicine
    2. Stem Cells and Regenerative Medicine

    Persistent epigenetic memory impedes rescue of the telomeric phenotype in human ICF iPSCs following DNMT3B correction

    Shir Toubiana et al.
    Correction of the DNA methyltransferase 3B gene in ICF1 syndrome fails to rescue the abnormal DNA hypomethylation at subtelomeric regions due to accompanied epigenetic abnormalities in these regions.
    1. Neuroscience

    DeepPoseKit, a software toolkit for fast and robust animal pose estimation using deep learning

    Jacob M Graving et al.
    A new deep-learning software toolkit with general-purpose methods for quickly and reliably measuring the full body posture of animals directly from images or videos without physical markers.
    1. Cancer Biology
    2. Computational and Systems Biology

    A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity

    Adam C Palmer et al.
    Drugs in a curative chemotherapy regimen are independently effective and resisted by different mechanisms, so cancer cells have little chance of surviving all drugs, and this benefit occurs without synergistic interactions.
    1. Developmental Biology
    2. Neuroscience

    Receptor-specific interactome as a hub for rapid cue-induced selective translation in axons

    Max Koppers et al.
    Multiple axonal guidance receptors control the local and selective translation of mRNAs by binding to ribosomes, specific mRNAs and RNA-binding proteins.
    1. Neuroscience

    Reliability of an interneuron response depends on an integrated sensory state

    May Dobosiewicz et al.
    A pair of interneurons in C. elegans condenses information from multiple sensory neurons into a uniform response, using an AND-gate logic to represent a stimulus with positive valence.
    1. Structural Biology and Molecular Biophysics

    The HCN domain couples voltage gating and cAMP response in hyperpolarization-activated cyclic nucleotide-gated channels

    Alessandro Porro et al.
    Experimental and computational approaches reveal how ligand binding is coupled to voltage sensing in a HCN channels.
    1. Neuroscience

    Single cell transcriptome atlas of the Drosophila larval brain

    Clarisse Brunet Avalos et al.
    Single-cell transcriptomics identifies cellular composition of the first instar Drosophila brain and the response to starvation.
    1. Neuroscience

    High-throughput microcircuit analysis of individual human brains through next-generation multineuron patch-clamp

    Yangfan Peng et al.
    Combining a multineuron patch-clamp system with an automated pipette pressure and cleaning device enables efficient screening of synaptic connectivity in human brain slices and allows inter-individual comparison.
    1. Genetics and Genomics

    Extensive impact of low-frequency variants on the phenotypic landscape at population-scale

    Téo Fournier et al.
    Genome-wide association studies on a diallel yeast panel revealed the relevance of low-frequency variants on the phenotypic diversity and consequently on the missing heritability at a population-scale.
    1. Genetics and Genomics

    Rare variants contribute disproportionately to quantitative trait variation in yeast

    Joshua S Bloom et al.
    Rare, evolutionarily recent variants have larger effect sizes and are more likely to decrease fitness, providing evidence that quantitative traits in yeast have evolved under purifying selection.