1,708 results found
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon, Sarah E Lower ... Jing-Ke Weng
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Neuroscience

    Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

    François Kroll, Joshua Donnelly ... Jason Rihel
    Revised
    Reviewed Preprint v2
    Updated
    • Important
    • Solid
    1. Neuroscience

    Light sets the brain’s daily clock by regional quickening and slowing of the molecular clockworks at dawn and dusk

    Suil Kim, Douglas G McMahon
    Light signals adjusting the brain's daily clock induce distinct waveform changes in molecular clock gene rhythms at dawn and dusk, and trigger regionally differential clock changes.
    1. Neuroscience

    Control of innate olfactory valence by segregated cortical amygdala circuits

    James R Howe, Chung-Lung Chan ... Cory M Root
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Cell Biology

    Stratification of enterochromaffin cells by single-cell expression analysis

    Yan Song, Linda J. Fothergill ... Gene W. Yeo
    Not revised
    Reviewed Preprint v1
    • Valuable
    • Solid
    1. Computational and Systems Biology
    2. Developmental Biology

    Discovering sparse transcription factor codes for cell states and state transitions during development

    Leon A Furchtgott, Samuel Melton ... Sharad Ramanathan
    Sparse patterns in gene expression allow simultaneous discovery of cell states, lineage relationships and key genes controlling developmental decisions.
    1. Cancer Biology

    The integration of Tgfβ and Egfr signaling programs confers the ability to lead heterogeneous collective invasion

    Apsra Nasir, Sharon Camacho ... Gray W. Pearson
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    1. Immunology and Inflammation
    2. Medicine

    Bacterial–fungal interactions in the neonatal gut influence asthma outcomes later in life

    Rozlyn CT Boutin, Charisse Petersen ... B Brett Finlay
    Overgrowth of the yeast Pichia kudriavzevii within the neonatal gut microbiota increases allergic airway disease severity later in life and may be inhibited by short-chain fatty acids.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    MftG is crucial for ethanol metabolism of mycobacteria by linking mycofactocin oxidation to respiration

    Ana Patrícia Graça, Vadim Nikitushkin ... Gerald Lackner
    Revised
    Reviewed Preprint v3
    Updated
    • Fundamental
    • Compelling

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