394 results found
    1. Human Biology and Medicine
    2. Neuroscience

    Deficit of mitogen-activated protein kinase phosphatase 1 (DUSP1) accelerates progressive hearing loss

    Adelaida M Celaya et al.
    Mitogen-activated protein kinase phosphatase 1 (DUSP1) deficiency causes early redox imbalance and increased inflammatory response in the cochlea, leading to cell loss and progressive neurosensory hearing loss.
    1. Cell Biology
    2. Computational and Systems Biology

    Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

    Nona Farbehi et al.
    Comprehensive scRNA-seq analysis of cardiac stromal cells in healthy and injured hearts reveals novel cell types and non-linear cell dynamics, providing new insights into cardiac inflammation, fibrosis and repair.
    1. Microbiology and Infectious Disease

    Transcriptional down-regulation of ccr5 in a subset of HIV+ controllers and their family members

    Elena Gonzalo-Gil et al.
    A subset of EC/VCs have CD4+T cells with resistance specific to R5-tropic HIV infection associated with transcriptional down-regulation of ccr5, a phenotype that appears to be heritable, across multiple generations.
    1. Chromosomes and Gene Expression

    Intergenerational epigenetic inheritance of cancer susceptibility in mammals

    Bluma J Lesch et al.
    Genetic knockout of the histone demethylase Kdm6a in the mouse germ line leads to elevated cancer incidence in genetically wild type offspring.
    1. Developmental Biology

    Distinct mesoderm migration phenotypes in extra-embryonic and embryonic regions of the early mouse embryo

    Bechara Saykali et al.
    At gastrulation, mesoderm arises as a migratory germ layer that will participate to both foetal and placental development through region-dependant adaptation of cytoskeleton composition, cell shape and migration mode.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Cryo-EM reveals distinct conformations of E. coli ATP synthase on exposure to ATP

    Meghna Sobti et al.
    Cryo-EM studies reveal that incubation with ATP produces conformational intermediates of E. coli ATP synthase, in which the ε subunit is no longer in its autoinhibitory conformation.
    1. Human Biology and Medicine
    2. Neuroscience

    Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

    Federica Storti et al.
    Lipid efflux by the retinal pigment epithelium is crucial for proper retinal integrity and function, and its impairment may contribute to diseases like age-related macular degeneration.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming

    Mirko Francesconi et al.
    Variation in efficiency, speed and path during transdifferentiation and reprogramming originates from two pre-B cell subpopulations with reciprocal propensity towards each fate conversion.

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