Valerie Ann Perez, David W Sanders ... Marc I Diamond
Knockout of the J domain protein DnaJC7 reduces tau aggregate clearance and increases intracellular tau seeding for recombinant and human brain-derived tau seed sources.
In lung adenocarcinoma, deleting one glucose transporter, whether it is Glut1 or Glut3 is insufficient, whereas their dual deletion reduces tumor growth.
A novel antibody recognizing receptor-binding region of MARV glycoprotein was developed and displays broad-spectrum neutralizing activity to filovirus species when NPC2 was fused to the N-terminus of the mAb.
Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in fibrotic fibroblasts.
The combination of in vitro investigations, the zebrafish screening model and rodent experiments offered a unique approach to optimizing nanoparticles modified with Hepatitis B virus-derived peptides to specifically target hepatocytes.
Computer visualization techniques developed for video games can be repurposed to enable viewers to explore cells and their environment in three dimensions.
Electrical and biomechanical stimuli directly bias cortical signal transduction and cytoskeletal waves, and the direct bias induced by an electric field develops slowly compared to the rapid surface-receptor-mediated response to chemotactic gradients.
