27 results found
    1. Cell Biology

    Neurofibromin controls macropinocytosis and phagocytosis in Dictyostelium

    Gareth Bloomfield et al.
    Inactivation of the Dictyostelium orthologue of the tumour suppressor Neurofibromin (NF1) enables amoebae to ingest dissolved nutrients using macropinocytosis more rapidly, and to prey on larger organisms using phagocytosis.
    1. Cell Biology
    2. Ecology

    Ubiquitous macropinocytosis in anthozoans

    Philippe Ganot et al.
    Macropinocytosis, the process of non-specific endocytosis, is a major gateway for large volumes of surrounding medium and nanoparticles to coral cells.
    1. Cell Biology

    A plasma membrane template for macropinocytic cups

    Douwe M Veltman et al.
    Rings of actin polymerisation that form around PIP3/Ras patches in the cell membrane drive the formation of macropinocytic cups.
    1. Cell Biology
    2. Human Biology and Medicine

    Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

    Hongyun Zhao et al.
    Exosomes from cancer-associated fibroblasts enhance the "Warburg effect" in tumors and contain de novo metabolites that can contribute to the entire compendia of central carbon metabolism within cancer cells.
    1. Cell Biology
    2. Human Biology and Medicine

    Cancer Metabolism: Partners in the Warburg effect

    Joshua D Rabinowitz, Hilary A Coller
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    1. Cell Biology
    2. Neuroscience

    Small molecule induced oligomerization, clustering and clathrin-independent endocytosis of the dopamine transporter

    Tatiana Sorkina et al.
    Dopamine transporter (DAT) interaction with furopyrimidine called AIM-100 in intact cells leads to dramatic oligomerization, nanoclustering and endocytosis of DAT by a novel mechanism coupled to the transporter molecule conformation.
    1. Cancer Biology

    Hyperactivation of ERK by multiple mechanisms is toxic to RTK-RAS mutation-driven lung adenocarcinoma cells

    Arun M Unni et al.
    Cancer cells driven by mutations in KRAS or EGFR are dependent on DUSP6 to prevent ERK-induced cell death, creating a novel vulnerability for targeted therapy.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Chemotactic network responses to live bacteria show independence of phagocytosis from chemoreceptor sensing

    Netra Pal Meena, Alan R Kimmel
    Eukaryotic chemotaxis to live bacteria was quantified at a high throughput level, for the first time, and mechanistically examined for the interrelationship between chemotaxis and phagocytosis.
    1. Biochemistry and Chemical Biology
    2. Cancer Biology

    Targeting RAS-driven human cancer cells with antibodies to upregulated and essential cell-surface proteins

    Alexander J Martinko et al.
    Proteomics and functional genomics coupled to an antibody discovery pipeline revealed the influence of oncogenic RAS signaling on the cell-surface proteome and resulted in the discovery of potential therapeutic targets for RAS-driven cancers.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Dynamics of mTORC1 activation in response to amino acids

    Maria Manifava et al.
    Activation by amino acids causes mTORC1 to translocate transiently to the lysosomal surface.

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