Sara Zeppilli, Tobias Ackels ... Alexander Fleischmann
Different subtypes of projection neurons in the mouse olfactory bulb are defined by distinct gene expression patterns and transcription factor networks.
Torsten M Scheyer, John R Hutchinson ... Marcelo R Sánchez-Villagra
The giant caiman Purussaurus from the Miocene of Venezuela is the first recorded member of crown Crocodylia having three sacrals, thus breaking the otherwise strict vertebral constraint of the group.
Marco Novais-Cruz, Maria Alba Abad ... Cristina Ferrás
Direct live-cell imaging of human cells, combined with RNA-seq, qPCR and in vitro reconstitution essays, reveal that mitotic progression, arrest, exit or death is independent of de novo transcription.
Taylor ET Hughes, John Smith Del Rosario ... Vera Y Moiseenkova-Bell
Structure-based virtual screening reveals multiple novel TRPV5 inhibitors that bind and exert their effect from previously unidentified binding sites as characterized by cryo-electron microscopy and electrophysiology.
Single-cell sequencing and functional analysis identify T cells that can be useful for marker selection and cell therapy in uveal melanoma, a disease largely unresponsive to conventional immune checkpoint therapies.
Sara Scinicariello, Adrian Soderholm ... Gijs A Versteeg
HUWE1 indirectly mediates the return to cellular homeostasis after pro-inflammatory responses, which it does by controling the stability of the immune suppressor tristetraprolin.
A novel, overlapping, putatively functional gene in SARS-CoV-2, ORF3d, is absent from close relatives of SARS-CoV-2 and may have contributed to the biology, emergence, or spread of the virus.
Caenorhabditis elegans behavioral response to a mechanosensory signal depends on both the temporal properties of the signal, such as its rate of change, and the animal's current behavior state.
Modulation of histone levels in gut enterocytes by rapamycin treatment alters chromatin organisation and induces intestinal autophagy through transcriptional regulation to prevent age-related decline in the intestine and extend lifespan.
Stimulus-receptivity loss increases coupling of a sensory neuron to a second sensory circuit by upregulating neuropeptide receptors, enhancing output of the second circuit, and providing a mechanism for cross-modal plasticity.
