The RNA-mediated higher order assembly of TDP-43, a protein associated with neurodegenerative diseases, preserves its solubility by reducing the risk of multivalent interactions between low complexity domains.
Time-resolved transition metal ion fluorescence resonance energy transfer using a fluorescent, noncanonical amino acid donor and metal ion acceptor measures distances and distance distributions in proteins, allowing the equilibrium distributions among conformational states to be accurately determined.
With unique lesion-informed tractography, left hemisphere temporo-cerebellar structural connectivity has been established, supporting rapid auditory transmission and cortical functional lateralization.
METRIS is a method that reports a mechanical readout of protein-protein interactions and due to its unique properties, it will allow many protein-protein interactions to be quantitatively measured easily that are currently laborious to measure with conventional methods.
The variability of the pupil–fMRI relationship was characterized through a combination of clustering and prediction methods, which revealed brain state-specific subcortical and neuromodulatory activation patterns reflected in pupil dynamics.