7 results found
    1. Epidemiology and Global Health

    Evidence from a natural experiment that malaria parasitemia is pathogenic in retinopathy-negative cerebral malaria

    Dylan S Small et al.
    The sickle cell trait strongly protects against not only retinopathy-positive cerebral malaria but also retinopathy-negative cerebral malaria, providing evidence that malarial parasites also contribute to retinopathy-negative cerebral malaria and are not innocent bystanders.
    1. Human Biology and Medicine
    2. Neuroscience

    Neurovascular sequestration in paediatric P. falciparum malaria is visible clinically in the retina

    Valentina Barrera et al.
    Clinical, clinicopathological and image data from Malawian children shows that sequestration in P. falciparum cerebral malaria is visible clinically in the eye as orange retinal vessels and is strongly associated with death.
    1. Genetics and Genomics

    An internal promoter underlies the difference in disease severity between N- and C-terminal truncation mutations of Titin in zebrafish

    Jun Zou et al.
    The newly discovered Titin internal promoter may explain why the severity of dilated cardiomyopathy in patients with truncating mutations in Titin varies dramatically depending on position of the mutation.
    1. Neuroscience

    Insulin signaling controls neurotransmission via the 4eBP-dependent modification of the exocytotic machinery

    Rebekah Elizabeth Mahoney et al.
    By regulating protein translation within the neuron, insulin signaling can control neuronal activity by altering the release of neurotransmitter molecules.
    1. Computational and Systems Biology
    2. Developmental Biology

    Synchronization of endothelial Dll4-Notch dynamics switch blood vessels from branching to expansion

    Benedetta Ubezio et al.
    Increasing levels of the growth factor Vegfa disrupt blood vessel branching morphogenesis and drive diameter increase by synchronizing Notch signalling fluctuations between endothelial cells.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Functional trade-offs and environmental variation shaped ancient trajectories in the evolution of dim-light vision

    Gianni M Castiglione, Belinda SW Chang
    The evolution of the light-sensitive visual pigment rhodopsin involved functional tradeoffs that may have sacrificed rod photosensitivity for active-state protein stability to mitigate phototoxicity in tetrapods, but not in fishes.

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