1,195 results found
    1. Chromosomes and Gene Expression

    Successful transmission and transcriptional deployment of a human chromosome via mouse male meiosis

    Christina Ernst et al.
    Transmission of an entire human chromosome through the mouse male germline reveals an unexpectedly high tolerance of aneuploidy during male meiosis and results in accurate transcriptional deployment despite massive epigenetic remodeling during spermatogenesis.
    1. Stem Cells and Regenerative Medicine

    Transgenerational dynamics of rDNA copy number in Drosophila male germline stem cells

    Kevin L Lu et al.
    rDNA copy number is shown to dynamically change during aging and through generations, and is actively maintained in male germline of Drosophila.
    1. Stem Cells and Regenerative Medicine

    Klp10A, a stem cell centrosome-enriched kinesin, balances asymmetries in Drosophila male germline stem cell division

    Cuie Chen et al.
    Microtubule-depolymerizing kinesin, Klp10A, prevents overgrowth of the mother centrosome to prevent undesirable asymmetries during asymmetric divisions of Drosophila male germline stem cells.
    1. Developmental Biology
    2. Genetics and Genomics

    In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse

    Marco Morselli et al.
    DNA methylation deposition is dependent on the presence of H3K4me3 and H3K36me3 histone marks.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    The polarity protein Baz forms a platform for the centrosome orientation during asymmetric stem cell division in the Drosophila male germline

    Mayu Inaba et al.
    The stem cell orientation checkpoint senses the correct orientation of centrosomes via their interactions with a protein called Bazooka.
    1. Developmental Biology

    The conserved RNA helicase YTHDC2 regulates the transition from proliferation to differentiation in the germline

    Alexis S Bailey et al.
    Post-transcriptional control by YTHDC2 is required to turn off the mitotic proliferation program and facilitate proper expression of the meiotic program to allow a clean cell fate transition in the germline stem cell lineage.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    JNK signaling triggers spermatogonial dedifferentiation during chronic stress to maintain the germline stem cell pool in the Drosophila testis

    Salvador C Herrera, Erika A Bach
    JNK pathway activity induces spermatogonial dedifferentiation under challenging conditions to maintain the germline stem cell pool and to endow it with potentially fitter cells that have increased proliferation.
    1. Developmental Biology
    2. Evolutionary Biology

    Mating and male pheromone kill Caenorhabditis males through distinct mechanisms

    Cheng Shi et al.
    Male C. elegans die through two distinct mechanisms – mating-induced germline activation, and potent male pheromone toxicity – but the latter is unique to males of androdioecious species (made up of hermaphrodites and males).
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Hyperosmotic stress memory in Arabidopsis is mediated by distinct epigenetically labile sites in the genome and is restricted in the male germline by DNA glycosylase activity

    Anjar Wibowo et al.
    Transient adaptation to environmental fluctuations in plants is mediated through discrete epigenetic changes.
    1. Stem Cells and Regenerative Medicine

    Ovaries absent links dLsd1 to HP1a for local H3K4 demethylation required for heterochromatic gene silencing

    Fu Yang et al.
    A Drosophila fertility gene is identified that acts as a linker between HP1a and local H3K4 demethylation during HP1a-mediated gene silencing that is required for ovary development and transposon silencing..

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