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    1. Neuroscience

    Inhibitory CCK+ basket synapse defects in mouse models of dystroglycanopathy

    Jennifer N Jahncke, Daniel S Miller ... Kevin M Wright
    Loss of functional dystroglycan disrupts the formation and function of CCK+/CB1R+ inhibitory synapses in hippocampal CA1, resulting in reduced seizure thresholds in mouse models of dystroglycanopathy.
    1. Neuroscience

    The ciliary kinesin KIF7 controls the development of the cerebral cortex by acting differentially on SHH-signaling in dorsal and ventral forebrain

    María Pedraza, Valentina Grampa ... Justine Masson
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    DRAXIN regulates interhemispheric fissure remodelling to influence the extent of corpus callosum formation

    Laura Morcom, Timothy J Edwards ... Linda J Richards
    Incomplete interhemispheric fissure remodelling determines corpus callosum size in humans and BTBR N2 mice that carry a deletion in Draxin.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Asymmetric inheritance of centrosomes maintains stem cell properties in human neural progenitor cells

    Lars N Royall, Diana Machado ... Annina Denoth-Lippuner
    Genetic birthdating in forebrain organoids shows asymmetric inheritance of centrosomes in human neural progenitor cells, required for proper human neurogenesis.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    16p11.2 microdeletion imparts transcriptional alterations in human iPSC-derived models of early neural development

    Julien G Roth, Kristin L Muench ... Theo D Palmer
    A model of in vitro human corticogenesis identifies alterations in gene expression caused by loss of 16p11.2 CNV genes in hiPSC-derived progenitor cells.
    1. Neuroscience

    DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

    Eva On-Chai Lau, Devid Damiani ... Fadel Tissir
    DIAPH3 safeguards integrity of microtubule cytoskeleton during division of neural progenitor cells.
    1. Developmental Biology
    2. Neuroscience

    Maturation of Purkinje cell firing properties relies on neurogenesis of excitatory neurons

    Meike E van der Heijden, Elizabeth P Lackey ... Roy V Sillitoe
    Intersectional genetics show that excitatory neurons are essential for the functional and anatomical maturation of cerebellar circuits in mice.
    1. Neuroscience

    Gradient organisation of functional connectivity within resting state networks is present from 25 weeks gestation in the human fetal brain

    Jucha Willers Moore, Siân Wilson ... Vyacheslav R Karolis
    Not revised
    Reviewed Preprint v1
    • Important
    • Inadequate
    1. Developmental Biology
    2. Neuroscience

    Pleiotropic effects of trisomy and pharmacologic modulation on structural, functional, molecular, and genetic systems in a Down syndrome mouse model

    Sergi Llambrich, Birger Tielemans ... Greetje Vande Velde
    Ts65dn mice exhibit structural, functional, molecular, and genetic alterations that are modulated but unrecovered by prenatal chronic GTE-EGCG, highlighting the importance of holistic studies to understand complex disorders and treatments.
    1. Cell Biology
    2. Developmental Biology

    Analysis of cellular behavior and cytoskeletal dynamics reveal a constriction mechanism driving optic cup morphogenesis

    María Nicolás-Pérez, Franz Kuchling ... Juan R Martínez-Morales
    High-resolution live imaging analysis shows a constriction mechanism that drives zebrafish optic cup morphogenesis and highlights the role of the extracellular matrix in transmitting tensions beyond the cellular level.
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