Malonyl-CoA, the rate-limiting substrate for fatty acid synthesis, is produced in the soma and delivered through gap junctions to the germline to promote reproduction and coordinate it with nutritional status.

The pseudoenzyme CPT1C is able to sense changes in intracellular malonyl-CoA levels caused by nutrients or energy stress and regulate late endosomes/lysosomes anterograde transport, necessary for proper axon growth.

Volatile anesthetics impair hepatic tricarboxylic acid cycle function in adult and neonatal mice, with citrate accumulation driving a neonate-specific inhibition of beta-oxidation and ketosis through their increased relative sensitivity to malonyl-CoA.

Metabolic flux analysis, biochemistry assays, and functional confirmation in mice show that the ubiquitination and degradation of ATP-citrate lyase (ACLY) mediated by CUL3-KLHL25 promotes the switch from fatty acid synthesis to fatty acid oxidation for iTreg differentiation.

An acetyl-CoA-mediated metabolic and epigenetic network has been elucidated that stimulates histone acetylation and anti-oxidative stress gene expression for heart repair after myocardial infarction.

Skeletal muscle mitochondrial pyruvate carrier disruption increases muscle fatty acid oxidation and systemic glucose turnover that drive whole-body leanness.

Genome wide association analyses in a wild-derived Drosophila melanogaster population uncover extensive variation in cuticular hydrocarbon composition, which may present a target for natural selection and adaptive evolution.

Genome-scale metabolic modeling of individual cancer cells and healthy human cells identifies specific and selective metabolic vulnerabilities.

Biallelic variants in MCAT are associated with combined oxidative phosphorylation deficiency in humans and a clinical presentation that includes hypotonia, developmental delay, failure to thrive, and nystagmus.

A policing system in Bacillus velezensis coordinated extracellular matrix production and autotoxin synthesis/self-immunity to penalize cheater-like nonproducers in biofilm community, which enhances the population stability and ecological fitness under stress conditions and in the rhizosphere.