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    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    The aryl hydrocarbon receptor and interferon gamma generate antiviral states via transcriptional repression

    Tonya Kueck et al.
    Distinct antiviral signaling pathways, triggered by the aryl hydrocarbon receptor and Interferon-gamma, converge on CDK/cyclin repression, causing inhibition of viral DNA synthesis.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Immune genes are hotspots of shared positive selection across birds and mammals

    Allison J Shultz, Timothy B Sackton
    Pathogens, particularly viruses, target the same genes over deep evolutionary time, resulting in shared signatures of positive selection and transcriptional responses at the same genes.
    1. Neuroscience

    TrpV1 receptor activation rescues neuronal function and network gamma oscillations from Aβ-induced impairment in mouse hippocampus in vitro

    Hugo Balleza-Tapia et al.
    TrpV1 receptor activation rescues cognition-relevant network dynamics in mouse hippocampus in an acute Alzheimer disease model providing a novel therapeutic target.
    1. Neuroscience

    Sub-second dynamics of theta-gamma coupling in hippocampal CA1

    Lu Zhang et al.
    A combination of signal processing and machine learning form a new approach to classify oscillatory coupling in single cycles without averaging over time and to capture cycle-by-cycle changes in coupling.
    1. Neuroscience

    Resting-state gamma-band power alterations in schizophrenia reveal E/I-balance abnormalities across illness-stages

    Tineke Grent-'t-Jong et al.
    Resting-state MEG-activity and MRS-GABA/Glx measurements reveal that there is a significant shift in excitability during the course of schizophrenia, involving hyperexcitability during the onset and a reduction at chronic stages.
    1. Computational and Systems Biology
    2. Neuroscience

    A kinematic synergy for terrestrial locomotion shared by mammals and birds

    Giovanna Catavitello et al.
    General principles of the limb segment control for terrestrial locomotion have emerged in evolution and highlight the existence of the laws of biological motion that apply to various animal species.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Viruses are a dominant driver of protein adaptation in mammals

    David Enard et al.
    Viruses drive adaptation at the scale of the whole proteome and not only in antiviral proteins in mammalian hosts.
    1. Ecology
    2. Microbiology and Infectious Disease

    Immune-mediated hookworm clearance and survival of a marine mammal decrease with warmer ocean temperatures

    Mauricio Seguel et al.
    In years with colder ocean temperatures, fur seal pups receive more maternal care and have a better energy balance, clearing hookworm infection earlier, which increases their chances of survival.
    1. Ecology

    Mammal communities are larger and more diverse in moderately developed areas

    Arielle Waldstein Parsons et al.
    Citizen science camera trapping showing suburban and wild areas maintain similar levels of mammalian diversity and relative abundance, challenging conventional thoughts about the impacts of urbanization on wildlife.
    1. Neuroscience

    Analogue closed-loop optogenetic modulation of hippocampal pyramidal cells dissociates gamma frequency and amplitude

    Elizabeth Nicholson et al.
    Neurons can synchronize, supporting flexible communication among brain areas; closed-loop optogenetics allows the frequency and power of population oscillations to be dissociated, providing a tool to interrogate how networks couple.