1,367 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Constraint and divergence of global gene expression in the mammalian embryo

    Noah Spies et al.
    Embryonic gene expression is strongly influenced by maternal genetic variation and by embryonic variation that acts in cis but not in trans.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    Transitions in cell potency during early mouse development are driven by Notch

    Sergio Menchero et al.
    The Notch signaling pathway drives transitions in differentiation capacities during the gradual loss of potency that occurs in the preimplantation mouse embryo before the onset of the first lineage decisions.
    1. Developmental Biology

    Growth-factor-mediated coupling between lineage size and cell fate choice underlies robustness of mammalian development

    Néstor Saiz et al.
    A mechanistic basis is provided for the regulative ability of the mammalian embryo offering a long-sought explanation for coordinating cell behaviors at the population level ensuring robustness in developmental outcome.
    1. Cell Biology

    Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1

    Rebecca Rojansky et al.
    The uniparental inheritance of mammalian mitochondria results from elimination of paternal mitochondria by a mitophagic process that requires the E3 ubiquitin ligases PARKIN and MUL1.
    1. Developmental Biology

    Calcium handling precedes cardiac differentiation to initiate the first heartbeat

    Richard CV Tyser et al.
    High-resolution live imaging reveals how and when the mouse heart first starts to beat during development and how the onset of beating impacts on heart muscle cell maturation and heart formation.
    1. Developmental Biology

    Regulation of X-linked gene expression during early mouse development by Rlim

    Feng Wang et al.
    Single embryo RNA-seq combined with mouse genetics provides a comprehensive view on the roles of Rlim and Xist for the regulation of X-linked gene expression during early mouse embryogenesis.
    1. Computational and Systems Biology
    2. Developmental Biology

    Rapid changes in morphogen concentration control self-organized patterning in human embryonic stem cells

    Idse Heemskerk et al.
    Live cell imaging demonstrates that the dynamics of ligand presentation influence signaling through two closely related morphogen signaling pathways in dramatically different ways.
    1. Stem Cells and Regenerative Medicine

    Mammalian genes induce partially reprogrammed pluripotent stem cells in non-mammalian vertebrate and invertebrate species

    Ricardo Antonio Rosselló et al.
    Cells from vertebrate and invertebrate model systems can be reprogrammed into stem-like cells using mouse genes.
    1. Developmental Biology

    The transcription factor Pitx2 positions the embryonic axis and regulates twinning

    Angela Torlopp et al.
    In higher vertebrates, the position of the embryonic axis (the location at which gastrulation starts) is determined by the transcription factor Pitx2, which suggests that the mechanisms of this process, and hence those that regulate twinning, are related to those that set up the left–right axis.

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