778 results found
    1. Developmental Biology
    2. Genetics and Genomics

    Constraint and divergence of global gene expression in the mammalian embryo

    Noah Spies et al.
    Embryonic gene expression is strongly influenced by maternal genetic variation and by embryonic variation that acts in cis but not in trans.
    1. Stem Cells and Regenerative Medicine

    Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning

    Sophie M Morgani et al.
    Micropatterned differentiation of mouse pluripotent stem cells gives rise to regionally distinct cell types arising in embryos at gastrulation.
    1. Cell Biology

    mRNA Decay: How cells kill a "killer" messenger

    Cosmin Saveanu, Alain Jacquier
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    1. Developmental Biology
    2. Genetics and Genomics

    2018 Gairdner Awards: The discovery and importance of genomic imprinting

    Anne C Ferguson-Smith, Deborah Bourc'his
    Research into genomic imprinting has provided a foundation for the study of epigenetic mechanisms, especially during development, and has also shed light on a range of rare genetic disorders and common diseases.
    1. Stem Cells and Regenerative Medicine

    Cell Fate Choice: Ready, set, differentiate!

    Margarida Sancho, Tristan A Rodríguez
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    1. Developmental Biology
    2. Chromosomes and Gene Expression

    Science Forum: Considerations when investigating lncRNA function in vivo

    Andrew R Bassett et al.
    We discuss the methods available to understand lncRNA function in vivo, and highlight important considerations that should be taken into account when designing such experiments.
    1. Ecology
    2. Evolutionary Biology

    The Natural History of Model Organisms: C. elegans outside the Petri dish

    Lise Frézal, Marie-Anne Félix
    To leverage the tools, resources and knowledge that exist for C. elegans so that we can study ecology, evolution and other aspects of biology, we need to understand the natural history of this important model organism.
    1. Developmental Biology

    Cell Fate Choice: Survival of the fattest

    Sophie M Morgani, Joshua M Brickman
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