1,389 results found
    1. Cell Biology
    2. Developmental Biology

    The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

    Sophie M Morgani et al.
    Loss of the transcription factor Rreb1 results perturbs epithelial architecture during mouse development resulting in invasive cell behaviors, severe cardiovascular defects, and embryonic lethality.
    1. Genetics and Genomics

    PIE-1 SUMOylation promotes germline fates and piRNA-dependent silencing in C. elegans

    Heesun Kim et al.
    PIE-1 engages SUMO to preserve the embryonic germline fate and also to promote the assembly of a MEP-1/Mi-2/HDA-1 chromatin remodeling complex required for inherited Argonaute-mediated gene silencing in the adult hermaphrodite germline.
    1. Developmental Biology

    Competitive coordination of the dual roles of the Hedgehog co-receptor in homophilic adhesion and signal reception

    Shu Yang et al.
    The apparently incompatible functions of the Hedgehog co-receptor Ihog in homophilic adhesion and ligand binding cooperate in Hh transport and reception.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Psychomotor impairments and therapeutic implications revealed by a mutation associated with infantile Parkinsonism-Dystonia

    Jenny I Aguilar et al.
    A dopamine transporter deficiency syndrome (DTDS)-linked mutation, R445C, underlies dopamine dysfunction and, more broadly, the clinical phenotypes shared by DTDS and Parkinson’s disease.
    1. Developmental Biology

    HDAC1 SUMOylation promotes Argonaute-directed transcriptional silencing in C. elegans

    Heesun Kim et al.
    HDAC SUMOylation promotes the association of other chromatin remodeling factors with the nuclear Argonaute WAGO-9, which is required for de novo heterochromatin silencing.
    1. Cell Biology

    Receptor-mediated mitophagy regulates EPO production and protects against renal anemia

    Guangfeng Geng et al.
    Fundc1-mediated mitophagy protects renal EPO-producing cells from myofibroblastic conversion under stresses.
    1. Cell Biology
    2. Developmental Biology

    EXOC1 plays an integral role in spermatogonia pseudopod elongation and spermatocyte stable syncytium formation in mice

    Yuki Osawa et al.
    EXOC1 contributes to the proper differentiation balance of spermatogonial stem cells and spermatocyte syncytia formation by regulating the morphology of male germ cells.
    1. Developmental Biology

    A calcineurin-mediated scaling mechanism that controls a K+-leak channel to regulate morphogen and growth factor transcription

    Chao Yi et al.
    Calcineurin regulates an electrophysiological mechanism that activates the transcription of specific developmental genes in a heirarchical manner to scale fish appendages.
    1. Chromosomes and Gene Expression

    Chromatin structure-dependent histone incorporation revealed by a genome-wide deposition assay

    Hiroaki Tachiwana et al.
    A new method using permeabilized cells and recombinant histones enables to analyze histone incorporations at the DNA sequence level.
    1. Neuroscience

    DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction

    Eva On-Chai Lau et al.
    DIAPH3 safeguards integrity of microtubule cytoskeleton during division of neural progenitor cells.

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