3,129 results found
  1. Episode 3: August 2013

    Episode 3: August 2013

    In this episode we hear about the cocktail party effect, the role of psuedogene RNA in the immune response, the genetic origins of a common form of blindness, the flu vaccine, and the origins of schistosomiasis.
    1. Ecology
    2. Evolutionary Biology
    The Natural History of Model Organisms

    The Natural History of Model Organisms

    Edited by Ian Baldwin et al.
    Essays on the wild lives of model organisms, from Arabidopsis to the zebrafish.
    1. Chromosomes and Gene Expression
    2. Cell Biology

    Aging, Geroscience and Longevity: A Special Issue

    Edited by Matt Kaeberlein et al.
    eLife is pleased to present a Special Issue to highlight recent advances in the mechanistic understanding of aging and interventions that extend longevity.
    1. Immunology and Inflammation

    RNF41 regulates the damage recognition receptor Clec9A and antigen cross-presentation in mouse dendritic cells

    Kirsteen M Tullett et al.
    Dendritic cell recognition and processing of antigens from dead cells, utilising the Clec9A-damage recognition receptor, is controlled by a novel RNF41-ubiquitin-mediated regulatory pathway.
    1. Cell Biology
    2. Developmental Biology

    Dot1l interacts with Zc3h10 to activate Ucp1 and other thermogenic genes

    Danielle Yi et al.
    Dot1l and its H3K79 methyltransferase activity are required for thermogenesis, and Dot1l is recruited by Zc3h10 to its targets genes to alter chromatin accessibility to activate the thermogenic gene program.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genetic mapping of etiologic brain cell types for obesity

    Pascal N Timshel et al.
    Unbiased computational integration of single-cell- and human genetics data shows that susceptibility to obesity is driven by a broad set of neuronal populations across the brain.
    1. Cell Biology
    2. Genetics and Genomics

    The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair

    Tao Huang et al.
    ZCWPW1 is a histone modification reader that localizes to DMC1-labelled double-strand break hotspots in a largely PRDM9-dependent manner, where it facilitates completion of synapsis by mediating DSB repair process.
    1. Developmental Biology
    2. Genetics and Genomics

    Smchd1 is a maternal effect gene required for genomic imprinting

    Iromi Wanigasuriya et al.
    Imprinted gene expression is set up during a critical window of early embryonic development, by the translation of parental imprints by oocyte-supplied Smchd1 into allele-specific gene silencing.
    1. Neuroscience

    Selective dendritic localization of mRNA in Drosophila mushroom body output neurons

    Jessica Mitchell et al.
    Specific mRNAs localize to the dendrites of Drosophila mushroom body output neurons.
    1. Cell Biology
    2. Neuroscience

    Pregnancy-associated plasma protein-aa regulates endoplasmic reticulum–mitochondria associations

    Mroj Alassaf, Mary C Halloran
    An extracellular modulator of IGF1 signaling, Pappaa, regulates endoplasmic reticulum–mitochondria connections, which are critical for metabolic homeostasis and hair cell survival.

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