93 results found
    1. Cell Biology
    2. Plant Biology

    Fluorescent sensors reporting the activity of ammonium transceptors in live cells

    Roberto De Michele, Cindy Ast ... Wolf B Frommer
    A modified form of Green Fluorescent Protein integrated into an ammonium transporter provides a sensor that can be used to monitor transport activity in vivo.
    1. Chromosomes and Gene Expression
    2. Evolutionary Biology

    Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair

    Rose T Byrne, Audrey J Klingele ... Michael M Cox
    Experiments on E. coli show that multiple mechanisms contribute to extreme resistance to ionizing radiation in bacteria, with mutations to three genes for DNA repair having a prominent role in one evolved population.
    1. Ecology
    2. Epidemiology and Global Health

    Hidden shift of the ionome of plants exposed to elevated CO2 depletes minerals at the base of human nutrition

    Irakli Loladze
    Increasing levels of atmospheric carbon dioxide reduce the mineral content but increase the levels of starch and sugars found in crop plants; which could exacerbate both obesity and malnutrition in some human populations.
    1. Cell Biology

    Ki-67 is a PP1-interacting protein that organises the mitotic chromosome periphery

    Daniel G Booth, Masatoshi Takagi ... Paola Vagnarelli
    The mitotic chromosome periphery is organised by the PP1 binding protein Ki-67 and contributes to nucleolar re-activation upon mitotic exit.
    1. Cell Biology

    Metal Transport: Pumping iron

    Caroline C Philpott
    Version of Record
    Insight
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome

    Alessandro Costa, Ludovic Renault ... James M Berger
    The Mcm2-7 motor unwinds DNA using an approach distinct from that of superfamily III helicases, and accesses multiple ring configurations and assembly states during the initiation of DNA replication.
    1. Structural Biology and Molecular Biophysics

    Sequence co-evolution gives 3D contacts and structures of protein complexes

    Thomas A Hopf, Charlotta P I Schärfe ... Debora S Marks
    Interactions in protein complexes can be predicted from evolutionary information from genomic sequences.
    1. Biochemistry and Chemical Biology

    The glucuronyltransferase B4GAT1 is required for initiation of LARGE-mediated α-dystroglycan functional glycosylation

    Tobias Willer, Kei-ichiro Inamori ... Kevin P Campbell
    Post-phosphoryl modification of α-dystroglycan requires the glucuronyltransferase B4GAT1; this enzyme synthesizes the acceptor glycan that serves as a primer for the glycosyltransferase LARGE to synthesize the laminin-binding glycan.
    1. Ecology
    2. Microbiology and Infectious Disease

    Mapping microbial ecosystems and spoilage-gene flow in breweries highlights patterns of contamination and resistance

    Nicholas A Bokulich, Jordyn Bergsveinson ... David A Mills
    Mapping microbial landscapes in indoor environments can predict how contaminants and spoilage resistance genes propagate within food-production environments, yielding novel insight for controlling spoilage.
    1. Evolutionary Biology

    Geological and taphonomic context for the new hominin species Homo naledi from the Dinaledi Chamber, South Africa

    Paul HGM Dirks, Lee R Berger ... Steven Tucker
    A new hominin species found in a South African cave is part of one of the most unusual hominin fossil assemblages on record.

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