1,577 results found
    1. Neuroscience

    ErbB4 deletion in noradrenergic neurons in the locus coeruleus induces mania-like behavior via elevated catecholamines

    Shu-Xia Cao, Ying Zhang ... Xiao-Ming Li
    Behavioral and molecular mechanistic studies elaborate the important role of ErbB4 in noradrenergic neurons associated with mania pathogenesis.
    1. Computational and Systems Biology
    2. Neuroscience

    High-resolution volumetric imaging constrains compartmental models to explore synaptic integration and temporal processing by cochlear nucleus globular bushy cells

    George A Spirou, Matthew Kersting ... Paul B Manis
    Volume electron-microscopic reconstructions of auditory brainstem neurons and their afferent synapses were used to develop a pipeline creating biophysically defined computational models with heterogenous inputs, revealing roles for subthreshold synapses to enhance temporal processing unique features of their dendrites.
    1. Structural Biology and Molecular Biophysics

    Structure-based analysis of CysZ-mediated cellular uptake of sulfate

    Zahra Assur Sanghai, Qun Liu ... Filippo Mancia
    Structures of CysZ show a antiparallel membrane protein with an unanticipated fold and together with functional characterization provide insight into a bacterial sulfate translocating system.
    1. Structural Biology and Molecular Biophysics

    Structural model for differential cap maturation at growing microtubule ends

    Juan Estévez-Gallego, Fernando Josa-Prado ... Maria A Oliva
    The tubulin GTPase cycle structurally modulates the microtubule cap, causing lattice expansion, which is an intermediate state involved in phosphate release and regulatory signaling.
    1. Developmental Biology

    Species-specific maturation profiles of human, chimpanzee and bonobo neural cells

    Maria C Marchetto, Branka Hrvoj-Mihic ... Fred H Gage
    Using iPSCs as a model to study neurodevelopmental differences between human and nonhuman primates lays the groundwork for understanding aspects of human brain evolution and neurological disease susceptibility.
    1. Developmental Biology
    2. Physics of Living Systems

    Emergence of a geometric pattern of cell fates from tissue-scale mechanics in the Drosophila eye

    Kevin D Gallagher, Madhav Mani, Richard W Carthew
    Formation of a triangular lattice of photoreceptor clusters in the compound eye is driven by highly regulated cell flows in the eye epithelium, through a mechanochemical mechanism.
    1. Neuroscience

    Neural circuitry coordinating male copulation

    Hania J Pavlou, Andrew C Lin ... Stephen F Goodwin
    A circuit consisting of motor neurons, inhibitory interneurons and mechanosensory neurons controls copulatory behaviour in male fruit flies.
    1. Developmental Biology
    2. Physics of Living Systems

    Global constraints within the developmental program of the Drosophila wing

    Vasyl Alba, James E Carthew ... Madhav Mani
    A novel mathematical strategy for the integrated analysis of adult body structures quantifies the degree and nature of developmental robustness and its evolutionary implications.
    1. Developmental Biology

    The Wg and Dpp morphogens regulate gene expression by modulating the frequency of transcriptional bursts

    Rachael Bakker, Madhav Mani, Richard W Carthew
    Experimental results in Drosophila support a model in which gene expression is fundamentally controlled by morphogens tuning the same transcription parameter for genes that are expressed in highly diverse patterns.
    1. Neuroscience

    Slow fluctuations in ongoing brain activity decrease in amplitude with ageing yet their impact on task-related evoked responses is dissociable from behavior

    Maria Ribeiro, Miguel Castelo-Branco
    The explanation of why older people show increased behavioral variability despite having decreased neural signal variability lies in the link between the dynamics of the ongoing neural signal and the trial-by-trial variability of neural evoked responses.

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