11,795 results found
    1. Neuroscience

    Dreaming with hippocampal damage

    Goffredina Spanò, Gloria Pizzamiglio ... Eleanor A Maguire
    A provoked awakening protocol during sleep reveals that selective bilateral hippocampal damage in humans is associated with reduced frequency, quality, and content of dreaming.
    1. Cell Biology
    2. Physics of Living Systems

    Exceptional stability of a perilipin on lipid droplets depends on its polar residues, suggesting multimeric assembly

    Manuel Giménez-Andrés, Tadej Emeršič ... Alenka Čopič
    The amphipathic helix of perilipin 4 relies on the organization of its polar residues to form a remarkably immobile and stable protein layer on the surface of lipid droplets.
    1. Structural Biology and Molecular Biophysics

    A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl/H+ transport cycle

    Tanmay S Chavan, Ricky C Cheng ... Merritt Maduke
    Crystallography together with electron-resonance spectroscopy, molecular-dynamics simulations, and transport measurements reveal the molecular details of protein conformational change, and how this change contributes to function in a CLC-type chloride/proton exchanger.
    1. Neuroscience

    Conduction velocity along a key white matter tract is associated with autobiographical memory recall ability

    Ian A Clark, Siawoosh Mohammadi ... Eleanor A Maguire
    A new magnetic resonance brain imaging measure reveals that variations in people’s ability to recall their past experiences may be related to the speed at which electrical signals travel along axons in the parahippocampal cingulum bundle.
    1. Neuroscience

    Charting brain growth and aging at high spatial precision

    Saige Rutherford, Charlotte Fraza ... Andre F Marquand
    During an individual's lifetime, their brain undergoes a unique transformation that we have precisely mapped across thousands of people to create and share reference growth charts of the human brain's lifespan which allow for single subject exploration and inference.
    1. Structural Biology and Molecular Biophysics

    Revealing an outward-facing open conformational state in a CLC Cl/H+ exchange transporter

    Chandra M Khantwal, Sherwin J Abraham ... Merritt Maduke
    The characterization of a previously unidentified “outward-facing open” conformational state provides a new framework for understanding the CLC transport mechanism.
    1. Neuroscience

    A spike sorting toolbox for up to thousands of electrodes validated with ground truth recordings in vitro and in vivo

    Pierre Yger, Giulia LB Spampinato ... Olivier Marre
    A spike sorting toolbox to quickly and reliably access the activity of thousands of neurons recorded with dense extracellular probes.
    1. Cell Biology

    Ndc1 drives nuclear pore complex assembly independent of membrane biogenesis to promote nuclear formation and growth

    Michael Sean Mauro, Gunta Celma ... Shirin Bahmanyar
    Discovery of how cells couple addition of membranes with insertion of nuclear pore complexes to form and grow the nucleus.
    1. Immunology and Inflammation

    Formin-like 1β phosphorylation at S1086 is necessary for secretory polarized traffic of exosomes at the immune synapse in Jurkat T lymphocytes

    Javier Ruiz-Navarro, Sara Fernández-Hermira ... Manuel Izquierdo Pastor
    FMNL1β is phosphorylated on S1086 in a protein kinase C δ (PKCδ)-dependent manner and S1086-phosphorylated FMNL1β acts downstream of PKCδ to regulate centrosome and multivesicular bodies polarization to the immunological synapse and exosome release.
    1. Neuroscience

    Homeostatic regulation of rapid eye movement sleep by the preoptic area of the hypothalamus

    John J Maurer, Alexandra Lin ... Shinjae Chung
    Preoptic area of the hypothalamus is important for the homeostatic regulation of rapid eye movement sleep.

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