The biophysical diversity that is intrinsic to spiral ganglion neurons emerges as spatial gradients during early post-natal development and endures through subsequent maturation to likely contribute to sound intensity coding.
A quantitative analysis of the connectivity between photoreceptors and bipolar cells in the mouse retina based on electron microscopy data yields exceptions from established rules of outer retinal connectivity.
oMAP4 is a microtubule crosslinker that restricts motor driven microtubule motility and cooperates with microtubule motors in the establishment of paraxial microtubule arrangements in differentiating muscle cells.
Advances in techniques for analysing single cells and tissues have inspired an international effort to create comprehensive reference maps of all human cells - the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring and treating disease.
Targeting the differentiation regulators and/or AMPs of keratinocytes, rather than targeting immune cells, may be an alternative approach for topical anti-psoriatic treatment, an area with high need for new drugs.