Krithika Venkataraman, Nadav Shai ... Leslie B Vosshall
Two novel, tightly linked, and rapidly evolving genes encoding small secreted proteins are necessary for female mosquitoes to protect their retained eggs during extended periods of drought.
Victoria Cochran Xie, Jinyue Pu ... Bryan C Dickinson
Replicating experimental evolution from ancestral proteins shows that historical contingency steadily overwhelms chance and necessity as the primary cause of evolutionary variation in molecular sequences on long phylogenetic timescales.
Robert Kiewisz, Gunar Fabig ... Thomas Müller-Reichert
Comprehensive 3D electron tomography reconstructions of metaphase spindles in human tissue culture cells reveal that kinetochore-fibers broaden as they extend polewards, forming semi-direct connections to the pole, where they preferentially interact with the spindle network.
ZCWPW1 has co-evolved with PRDM9, in particular the PRDM9-SET domain, and although not involved in PRDM9's role in positioning recombination events, it is required for PRDM9's role in pairing chromosomes.
Developmental specialization of vomeronasal sensory neurons involves selective upregulation of endoplasmic reticulum genes in a subset of neurons along with a hypertrophic gyroid membrane architecture.
Jennifer M Lin, Tyler A Mitchell ... Paolo Emanuele Forni
In vivo genetic experiments show that aberrant expression of a transcription factor can compromise the functionality of neurons which is important to better understand the potential mechanisms underlying neuropathologies.
Morgan P Kain, Eloise B Skinner ... Erin A Mordecai
The role host and vector species play in pathogen transmission cycles is best quantified by integrating species' physiological and ecological competence.
In teleost fishes, the independent evolution of electrosensory systems was repeatedly associated with evolutionary changes in brain region scaling that were independent of changes in brain–body allometry.