Secretion and fibrillogenesis of collagen-I are separately controlled molecular pathways in the fibroblast, where surprisingly endocytic recycling is required for fibril formation and is increased in fibrotic fibroblasts.
Common mouse models of polycystic ovary syndrome (PCOS) have variable ability to recapitulate the increased GnRH pulse generator frequency thought to exist in women with PCOS.
Bernd K Gilsbach, Franz Y Ho ... Christian Johannes Gloeckner
The Parkinson’s protein Leucine-Rich Repeat Kinase 2 contains a GTPase as well as kinase domain and modulates its intrinsic GTPase activity by autophosphorylation of the P-loop residue threonine 1343.
Time-resolved tmFRET revealed structural and energetic changes induced by ligand binding with full agonist cAMP and partial agonist cGMP in the cyclic nucleotide-binding domain of the bacterial ion channel SthK.
A combined approach of genome sequencing and fluctuation assays shows that antibiotic pressure does not induce adaptive mutations in Mycobacterium smegmatis, supporting drug resistance as a consequence of phenotypic tolerance.
Galectin-9 directly binds to arabinogalactan (AG), leading to the identification of AG-specific monoclonal antibodies that effectively inhibit Mycobacterium tuberculosis growth, providing insights for novel tuberculosis therapies.
