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    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size

    Alessandro Bonfini, Adam J Dobson ... Nicolas Buchon
    The nutrient composition of food alters both the size of gut epithelial cells and the ability of the stem cell niche to control tissue turnover, resulting in changes in size at the organ level.
    1. Stem Cells and Regenerative Medicine

    Enhanced exercise and regenerative capacity in a mouse model that violates size constraints of oxidative muscle fibres

    Saleh Omairi, Antonios Matsakas ... Ketan Patel
    The concepts that oxidative muscle fibres cannot be large and that satellite cell number is the major determinant for effective regeneration are fundamentally challenged.
    1. Neuroscience

    Molecular and anatomical characterization of parabrachial neurons and their axonal projections

    Jordan L Pauli, Jane Y Chen ... Richard D Palmiter
    A guide summarizing the diversity of cell types in the parabrachial nucleus.
    1. Medicine

    Miniaturized 3D bone marrow tissue model to assess response to Thrombopoietin-receptor agonists in patients

    Christian A Di Buduo, Pierre-Alexandre Laurent ... Alessandra Balduini
    A 3D bone marrow niche that reproduces megakaryocyte differentiation and ex vivo platelet production from hematopoietic progenitors and iPSCs of thrombocytopenic patients predicts individual response to Eltrombopag accurately.
    1. Chromosomes and Gene Expression

    Serotonin signaling mediates protein valuation and aging

    Jennifer Ro, Gloria Pak ... Scott D Pletcher
    Serotonin modulates diet-dependent lifespan in flies.
    1. Genetics and Genomics
    2. Neuroscience

    Phenotypic impact of individual conserved neuronal microexons and their master regulators in zebrafish

    Laura Lopez-Blanch, Cristina Rodríguez-Marin ... Manuel Irimia
    Not revised
    Reviewed Preprint v1
    • Important
    • Convincing
    1. Neuroscience

    In vivo assessment of the neural substrate linked with vocal imitation accuracy

    Julie Hamaide, Kristina Lukacova ... Annemie Van der Linden
    Song learning accuracy can be predicted and traced in the structural properties of the brains of juvenile male zebra finches already at 20 days post-hatching.
    1. Cancer Biology

    Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

    Xiaochuan Shan, Juan Jose Fung ... Reproducibility Project: Cancer Biology
    Editors' Summary: This Replication Study has reproduced important parts of the original paper.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    R-Spondin Mimetic, SZN-043, Induced Proliferation and Wnt Activity, Two Features Deficient in Human Alcohol-Associated Liver Disease

    Trevor Fisher, Mehaben Patel ... Helene Baribault
    Not revised
    Reviewed Preprint v1
    • Important
    • Solid
    • Incomplete