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    1. Genetics and Genomics
    2. Immunology and Inflammation

    Effects of an IgE receptor polymorphism acting on immunity, susceptibility to infection, and reproduction in a wild rodent

    Klara M Wanelik, Mike Begon ... Steve Paterson
    Genetic variation can have multiple effects on different phenotypic traits in organisms living in the natural environment.
    1. Evolutionary Biology
    2. Genetics and Genomics
    Medaka illustration

    The Natural History of Model Organisms: The untapped potential of medaka and its wild relatives

    Leon Hilgers, Julia Schwarzer
    Studies of medaka and other ricefishes in the wild could provide insights in fields such as evolutionary biology, development and cancer research.
    1. Neuroscience

    Dual leucine zipper kinase is required for mechanical allodynia and microgliosis after nerve injury

    Josette J Wlaschin, Jacob M Gluski ... Claire E Le Pichon
    The DLK response pathway in neurons initiates the cascade of events leading to neuropathic pain after injury.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

    Anthony S Findley, Alan Monziani ... Francesca Luca
    Investigation of dynamic gene regulation across cell types and environments reveals new GxE regulatory loci that are important for disease.
    1. Neuroscience

    Early life stressful experiences escalate aggressive behavior in adulthood via changes in transthyretin expression and function

    Rohit Singh Rawat, Aksheev Bhambri ... Arpita Konar
    Hypothalamic TTR as a novel molecular player of stress-induced long-term impact on behavior.
    1. Cell Biology

    The negative adipogenesis regulator Dlk1 is transcriptionally regulated by Ifrd1 (TIS7) and translationally by its orthologue Ifrd2 (SKMc15)

    Ilja Vietor, Domagoj Cikes ... Lukas A Huber
    Ifrd1 and Ifrd2 were identified using knockout mice as new molecular players regulating via two discrete mechanisms the activity of the transcriptional regulator Dlk1 and thereby affecting adipocyte differentiation.
    1. Evolutionary Biology

    Evolution of Yin and Yang isoforms of a chromatin remodeling subunit precedes the creation of two genes

    Wen Xu, Lijiang Long ... Patrick T McGrath
    Gene sharing through different isoforms can precede the formation of independent genes.
    1. Biochemistry and Chemical Biology
    2. Computational and Systems Biology

    Genetic variation of putative myokine signaling is dominated by biological sex and sex hormones

    Leandro M Velez, Cassandra Van ... Marcus M Seldin
    Genetic architecture of muscle secreted protein functions are dominated by sex.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    Genome-wide detection of imprinted differentially methylated regions using nanopore sequencing

    Vahid Akbari, Jean-Michel Garant ... Steven JM Jones
    A genome-wide map of human allele-specific methylation using long-read sequencing detects novel imprinted DNA methylation events and reveals large blocks of subtle parent-of-origin bias in DNA methylation with mutual exclusive allelic H3K36me3 and H3K27me3 histone modifications.
    1. Neuroscience

    Estrogenic-dependent glutamatergic neurotransmission from kisspeptin neurons governs feeding circuits in females

    Jian Qiu, Heidi M Rivera ... Oline K Rønnekleiv
    Estrogen increases hypothalamic arcuate kisspeptin neuronal excitability and glutamate release to coordinate autonomic functions for maximizing reproductive success.