Julia M Marchingo, Linda V Sinclair ... Doreen A Cantrell
Myc-dependent induction of amino acid transporter expression in response to T cell receptor activation is essential to enable T cell proteome remodelling upon immune activation.
Genetic analyses using the fruit fly illustrate how neuronal system couples germline stem cell increase to an external cue, which is mating, through stem cell niche signaling.
Nora C Brown, Benjamin Gordon ... Mariana Federica Wolfner
A functional genetics approach reveals a novel role for odorant binding proteins in post-mating processes, with complex mechanisms of evolutionary change across closely related insect species.
After insemination, honeybee queens experience a rapid reduction in vision and flight performance, consistent with an ongoing sexual conflict over the number of mating flights that queens embark on.
A statistical method for summarizing single-cell gene expression data identifies normal and disease-specific transcriptional programs from an atlas of 57,600 cells.
Sierra M Barone, Alberta GA Paul ... Jonathan M Irish
Rare, virus-specific immune cells in human blood are automatically identified by machine learning algorithm T-REX and characterized for signature features needed for tracking and isolation.
Iodixanol supplementation provides a simple method for tuning the refractive index of live imaging media, which can greatly improve resolution and penetration depth in live imaging experiments.
Priya M Christensen, Jonathan Martin ... Kelli L Palmer
A previously unknown lipid modification by a bacterial antibiotic resistance enzyme was identified through the analysis of a family of antibiotic resistance enzyme sequences with a machine learning approach.