958 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    ketu mutant mice uncover an essential meiotic function for the ancient RNA helicase YTHDC2

    Devanshi Jain, M Rhyan Puno ... Scott Keeney
    The mouse gene Ythdc2 exemplifies an evolutionarily ancient family of crucial regulators of the transition from germline stem cell divisions to meiosis.
    1. Neuroscience
    2. Physics of Living Systems

    A Deep Learning Pipeline for Mapping in situ Network-level Neurovascular Coupling in Multi-photon Fluorescence Microscopy

    Matthew Rozak, James Mester ... Bojana Stefanovic
    Revised
    Reviewed Preprint v3
    Updated
    • Valuable
    • Incomplete
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Functional dynamic genetic effects on gene regulation are specific to particular cell types and environmental conditions

    Anthony S Findley, Alan Monziani ... Francesca Luca
    Investigation of dynamic gene regulation across cell types and environments reveals new GxE regulatory loci that are important for disease.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers

    Byron C Williams, Joshua J Filter ... Michael L Goldberg
    The mechanism of inhibition by unfair competition is central to determining the protein phosphorylation states that govern cell cycle transitions between M phase and interphase.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast

    Radhika A Varier, Theodora Sideri ... Folkert J van Werven
    N6-methyladenosine (m6A) reader Pho92 is directed by Paf1C to meiotic mRNAs in an m6A-dependent and independent manner and promotes CCR4-NOT-mediated mRNA decay of m6A modified transcripts contingent on translation.
    1. Developmental Biology

    Single-cell transcriptome reveals insights into the development and function of the zebrafish ovary

    Yulong Liu, Michelle E Kossack ... Bruce W Draper
    Single-cell transcriptomics of the zebrafish ovary identifies both major and minor cell types and provides a valuable resource for researchers interested in reproductive biology, stem cell biology, and aquatic toxicology.
    1. Developmental Biology
    2. Physics of Living Systems

    Characterization of convergent thickening, a major convergence force producing morphogenic movement in amphibians

    David R Shook, Jason WH Wen ... Ray E Keller
    Xenopus embryos use tissue surface tension to generate hoop-stress around the blastopore to help close it during gastrulation.
    1. Computational and Systems Biology
    2. Developmental Biology

    Size control of the inner ear via hydraulic feedback

    Kishore R Mosaliganti, Ian A Swinburne ... Sean G Megason
    Size regulation of the otic vesicle, the progenitor of the inner ear, is mediated by mechanical feedback involving fluid influx, hydraulic pressure, and tissue mechanics.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic atlas of the adult Drosophila ventral nerve cord

    Aaron M Allen, Megan C Neville ... Stephen F Goodwin
    A single-cell atlas of the adult fly VNC charts the types and properties of cells for future studies of brain development and function.
    1. Microbiology and Infectious Disease

    Differential requirements for cyclase-associated protein (CAP) in actin-dependent processes of Toxoplasma gondii

    Alex Hunt, Matthew Robert Geoffrey Russell ... Moritz Treeck
    Partially overlapping functions of a limited subset of actin binding proteins allow the parasite Toxoplasma gondii to achieve actin regulation required for complex cellular processes.

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