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    1. Plant Biology

    Dormancy-specific imprinting underlies maternal inheritance of seed dormancy in Arabidopsis thaliana

    Urszula Piskurewicz, Mayumi Iwasaki ... Luis Lopez-Molina
    A genomic imprinting program in the endosperm of Arabidopsis mature seeds is dynamically adjusted according to seed dormancy levels and regulates germination.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition

    Miranda Wang, Michael Ly ... Olivia S Rissland
    ME31B is a general repressor of gene expression in the Drosophila early embryo, repressing translation before the maternal-to-zygotic transition and stimulating mRNA decay after activation of the zygotic genome.
    1. Developmental Biology
    2. Genetics and Genomics

    Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition

    Xiao-Yong Li, Melissa M Harrison ... Michael B Eisen
    Drosophila melanogaster embryos undergo a dramatic genomic transformation in the hour preceding gastrulation, as thousands of promoters and regulatory regions become biochemically distinct before they become active.
    1. Developmental Biology

    Maternal Gdf3 is an obligatory cofactor in Nodal signaling for embryonic axis formation in zebrafish

    Brent W Bisgrove, Yi-Chu Su, H Joseph Yost
    Maternal Gdf3 and Nodal are interdependent obligatory cofactors in the fundamental patterning of the vertebrate embryonic axis of zebrafish.
    1. Developmental Biology
    2. Genetics and Genomics

    Epi-mutations for spermatogenic defects by maternal exposure to di(2-ethylhexyl) phthalate

    Yukiko Tando, Hitoshi Hiura ... Yasuhisa Matsui
    Gene analyses reveal the abnormal DNA methylation and expression of the genes essential for spermatogenesis as a cause of spermatogenic defects in offspring induced by maternal exposure of a chemical.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition

    Michael Zavortink, Lauren N Rutt ... Olivia S Rissland
    In fruit flies, maternally deposited RNA-binding proteins are removed during the maternal-to-zygotic transition via a mechanism of translational upregulation of Kondo, the key E2 enzyme, at egg activation.
    1. Developmental Biology

    Regionally distinct trophoblast regulate barrier function and invasion in the human placenta

    Bryan Marsh, Yan Zhou ... Robert Blelloch
    Single cell RNA-sequencing of distinct regions of the human placenta identifies a smooth chorion-specific cytotrophoblast population responsible for unique functions of the smooth chorion, including acting as a barrier and restricting invasion.
    1. Developmental Biology
    2. Genetics and Genomics

    Zygotic gene activation in the chicken occurs in two waves, the first involving only maternally derived genes

    Young Sun Hwang, Minseok Seo ... Jae Yong Han
    In Aves, the first wave of transcription is derived exclusively from the maternal genome.
    1. Chromosomes and Gene Expression

    Conversion of random X-inactivation to imprinted X-inactivation by maternal PRC2

    Clair Harris, Marissa Cloutier ... Sundeep Kalantry
    The PRC2 Polycomb complex made in the mouse oocyte prevents transcriptional inactivation of the maternal X-chromosome in the early embryo.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Mitotic fidelity requires transgenerational action of a testis-restricted HP1

    Mia T Levine, Helen M Vander Wende, Harmit S Malik
    Analysis of a spermiogenesis protein reveals a new chromatin requirement for synchrony between maternal DNA packaged in the egg and sperm-packaged paternal DNA in the first embryonic mitosis in Drosophila melanogaster.