4,407 results found
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    ME31B globally represses maternal mRNAs by two distinct mechanisms during the Drosophila maternal-to-zygotic transition

    Miranda Wang et al.
    ME31B is a general repressor of gene expression in the Drosophila early embryo, repressing translation before the maternal-to-zygotic transition and stimulating mRNA decay after activation of the zygotic genome.
    1. Chromosomes and Gene Expression
    2. Developmental Biology

    The E2 Marie Kondo and the CTLH E3 ligase clear deposited RNA binding proteins during the maternal-to-zygotic transition

    Michael Zavortink et al.
    In fruit flies, maternally deposited RNA-binding proteins are removed during the maternal-to-zygotic transition via a mechanism of translational upregulation of Kondo, the key E2 enzyme, at egg activation.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    RNA-Binding Proteins: A matter of balance

    Aaron D Gitler, John D Fryer
    New analyses shift the view that some forms of amyotrophic lateral sclerosis and frontotemporal dementia are due to defects in a single RNA-binding protein.
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    1. Cell Biology
    2. Developmental Biology

    Control of PNG kinase, a key regulator of mRNA translation, is coupled to meiosis completion at egg activation

    Masatoshi Hara et al.
    The kinase that controls maternal mRNA translation is regulated by phosphorylation of its activating subunit to restrict kinase activity to the developmental window between meiosis completion and early embryogenesis.
    1. Developmental Biology

    Identification of PNG kinase substrates uncovers interactions with the translational repressor TRAL in the oocyte-to-embryo transition

    Masatoshi Hara et al.
    The threonine kinase controls maternal mRNA translation phosphorylate components of the translational machinery, including translational repressors, which appear to inactivate to promote the oocyte-to-embryo transition.
    1. Neuroscience

    Axon TRAP reveals learning-associated alterations in cortical axonal mRNAs in the lateral amygdala

    Linnaea E Ostroff et al.
    A diverse assortment of mRNAs are present in projection axons in the adult forebrain and their translation is associated with new memory formation.
    1. Plant Biology

    Non-canonical RNA-directed DNA methylation participates in maternal and environmental control of seed dormancy

    Mayumi Iwasaki et al.
    Seed-specific and cold-induced DNA methylation is deposited in the seed progeny to form a transient and transgenerational memory of past environmental conditions to optimize seed germination timing.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling

    Mark E Lush et al.
    Several support cell populations balance progenitor maintenance with differentiation in zebrafish lateral line sensory organs.
    1. Biochemistry and Chemical Biology
    2. Human Biology and Medicine

    Unexpected similarities between C9ORF72 and sporadic forms of ALS/FTD suggest a common disease mechanism

    Erin G Conlon et al.
    Idiopathic patients along a complex motor neuron disease-dementia spectrum exhibit mRNA splicing changes that are due to multi-protein insolubility.
    1. Neuroscience

    Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

    Shuo-Chien Ling et al.
    Elevating FUS level by saturating autoregulation loop in mice causes aggressive motor neuron disease via disrupting protein and RNA homeostasis.

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