John W Biddle, Rosa Martinez-Corral ... Jeremy Gunawardena
The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.
A comprehensive analysis of mutant animal model shows the important role of KDM6B and how it cooperates with TFDP1 to achieve its functional specificity in regulating Trp53 expression to control the fate of cranial neural crest cells during palatogenesis.
New immigrants triggered fast uptake of a novel food in groupmates, who obtained information about it through muzzle contacts, opening up new questions about the role of dispersers in information flow around a population.
Understanding novel cell types and their evolutionary history is re-evaluated using single nuclei transcriptomic approaches and their inferred underlying gene regulatory networks.
The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
In vivo imaging reveals that gradually increased amount of glucose mediates the heterogeneous functional development of individual β-cells by activating its major downstream calcineurin/NFAT signaling pathway.
Radhika A Varier, Theodora Sideri ... Folkert J van Werven
N6-methyladenosine (m6A) reader Pho92 is directed by Paf1C to meiotic mRNAs in an m6A-dependent and independent manner and promotes CCR4-NOT-mediated mRNA decay of m6A modified transcripts contingent on translation.