349 results found
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Allosteric conformational ensembles have unlimited capacity for integrating information

    John W Biddle, Rosa Martinez-Corral ... Jeremy Gunawardena
    The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.
    1. Cell Biology
    2. Developmental Biology

    Cell volume changes contribute to epithelial morphogenesis in zebrafish Kupffer’s vesicle

    Agnik Dasgupta, Matthias Merkel ... Jeffrey D Amack
    During Kupffer's vesicle morphogenesis, cell volume anisotropy impacts cell shape changes.
    1. Developmental Biology

    KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis

    Tingwei Guo, Xia Han ... Yang Chai
    A comprehensive analysis of mutant animal model shows the important role of KDM6B and how it cooperates with TFDP1 to achieve its functional specificity in regulating Trp53 expression to control the fate of cranial neural crest cells during palatogenesis.
    1. Ecology

    Role of immigrant males and muzzle contacts in the uptake of a novel food by wild vervet monkeys

    Pooja Dongre, Gaëlle Lanté ... Erica van de Waal
    New immigrants triggered fast uptake of a novel food in groupmates, who obtained information about it through muzzle contacts, opening up new questions about the role of dispersers in information flow around a population.
    1. Developmental Biology
    2. Neuroscience

    A cellular and molecular analysis of SoxB-driven neurogenesis in a cnidarian

    Eleni Chrysostomou, Hakima Flici ... Uri Frank
    SoxB genes are sequentially expressed in cnidarian neurogenesis.
    1. Developmental Biology
    2. Evolutionary Biology

    New hypotheses of cell type diversity and novelty from orthology-driven comparative single cell and nuclei transcriptomics in echinoderms

    Anne Meyer, Carolyn Ku ... Veronica Hinman
    Understanding novel cell types and their evolutionary history is re-evaluated using single nuclei transcriptomic approaches and their inferred underlying gene regulatory networks.
    1. Genetics and Genomics

    Firefly genomes illuminate parallel origins of bioluminescence in beetles

    Timothy R Fallon, Sarah E Lower ... Jing-Ke Weng
    The first genomic view of beetle luciferase evolution indicates evolutionary independence of luciferase between fireflies and click-beetles, and provide valuable datasets which will accelerate the discovery of new biotechnological tools.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Acquisition of exogenous haem is essential for tick reproduction

    Jan Perner, Roman Sobotka ... Petr Kopacek
    The lack of haem biosynthetic and degradative pathways in ticks offers new strategies to combat these parasites.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    In vivo imaging of β-cell function reveals glucose-mediated heterogeneity of β-cell functional development

    Jia Zhao, Weijian Zong ... Yanmei Liu
    In vivo imaging reveals that gradually increased amount of glucose mediates the heterogeneous functional development of individual β-cells by activating its major downstream calcineurin/NFAT signaling pathway.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    N6-methyladenosine (m6A) reader Pho92 is recruited co-transcriptionally and couples translation to mRNA decay to promote meiotic fitness in yeast

    Radhika A Varier, Theodora Sideri ... Folkert J van Werven
    N6-methyladenosine (m6A) reader Pho92 is directed by Paf1C to meiotic mRNAs in an m6A-dependent and independent manner and promotes CCR4-NOT-mediated mRNA decay of m6A modified transcripts contingent on translation.

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