349 results found
    1. Computational and Systems Biology
    2. Microbiology and Infectious Disease

    Modeling transfer of vaginal microbiota from mother to infant in early life

    Martin Steen Mortensen, Morten Arendt Rasmussen ... Søren Johannes Sørensen
    Modeling weighted transfer ratios enable statistical analysis of maternal–infant transfer at a more general level and can indicate whether any transfer is persistent, transient, or originates from alternate sources.
    1. Cell Biology
    2. Developmental Biology

    Maternal spindle transfer overcomes embryo developmental arrest caused by ooplasmic defects in mice

    Nuno Costa-Borges, Katharina Spath ... Gloria Calderón
    Maternal spindle transfer is a feasible approach to enhance embryonic developmental of compromised oocytes, which can represent a new strategy for patients with forms of infertility refractory to current treatments.
    1. Computational and Systems Biology
    2. Medicine

    Development and evaluation of a live birth prediction model for evaluating human blastocysts from a retrospective study

    Hang Liu, Zhuoran Zhang ... Yu Sun
    The inclusion of the patient couple's clinical features along with blastocyst images increases live birth prediction accuracy.
    1. Developmental Biology
    2. Medicine

    Vertical transmission of maternal DNA through extracellular vesicles associates with altered embryo bioenergetics during the periconception period

    David Bolumar, Javier Moncayo-Arlandi ... Felipe Vilella
    In vitro analyses reveal how vertical DNA transmission from the mother to the pre-implantation embryo via endometrial extracellular vesicles can impact embryo bioenergetics.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Maternal diet-induced obesity during pregnancy alters lipid supply to mouse E18.5 fetuses and changes the cardiac tissue lipidome in a sex-dependent manner

    Lucas C Pantaleão, Isabella Inzani ... Susan E Ozanne
    Maternal obesity alters the fetal cardiac and serum lipidome, promoting early fetal cardiac metabolic maturation, with evidence that the female heart lipidome is more responsive to an in utero obesogenic environment.
    1. Biochemistry and Chemical Biology
    2. Developmental Biology

    Hormone-sensitive lipase couples intergenerational sterol metabolism to reproductive success

    Christoph Heier, Oskar Knittelfelder ... Ronald P Kühnlein
    An ancestral enzyme tailors allocation of essential lipid resources to the progeny and connects maternal and embryonic sterol metabolism for reproductive success.
    1. Developmental Biology
    2. Genetics and Genomics

    Fetal growth delay caused by loss of non-canonical imprinting is resolved late in pregnancy and culminates in offspring overgrowth

    Ruby Oberin, Sigrid Petautschnig ... Patrick S Western
    Growth-delayed offspring generated from eggs that lacked normal epigenetic programming exhibited a remarkable capacity to undergo late gestational fetal growth recovery, despite inefficient placental function.
    1. Developmental Biology

    Maternally provided LSD1/KDM1A enables the maternal-to-zygotic transition and prevents defects that manifest postnatally

    Jadiel A Wasson, Ashley K Simon ... David J Katz
    Epigenetic reprogramming by LSD1/KDM1A acts at fertilization in mice to enable embryogenesis and prevent behavioural abnormalities.
    1. Developmental Biology

    Placental uptake and metabolism of 25(OH)vitamin D determine its activity within the fetoplacental unit

    Brogan Ashley, Claire Simner ... Jane K Cleal
    Active uptake and metabolism of maternal vitamin D by the placenta determine fetal exposure to vitamin D and how vitamin D regulates the placental transcriptome, which is also determined by its underlying epigenetic landscape, and proteome.
    1. Evolutionary Biology

    Transition to siblinghood causes a substantial and long-lasting increase in urinary cortisol levels in wild bonobos

    Verena Behringer, Andreas Berghänel ... Gottfried Hohmann
    In wild bonobos, sibling birth induced a sudden increase in urinary cortisol levels in the older offspring, a physiological response that occurred in all subjects and was independent of their age.

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