An eco-evolutionary model shows that heterozygote advantage can maintain over 100 major histocompatibility complex alleles, providing a potent explanation for extraordinary immune gene diversity and challenges previous models that predicted limited allele coexistence.
A principle from which the neuronal dynamics and synaptic plasticity in arbitrary network architectures can be inferred, so that output errors are online minimized while simultaneously processing sensory input streams.
Fridtjof Brauns, Nikolas H Claussen ... Boris I Shraiman
Active and passive contributions to cell shape change and rearrangements can be distinguished from observed cell geometry, revealing the self-organization mechanisms underlying internally-driven epithelial convergent extension.
Kiss1ARH neurons transition from synchronous to burst firing under preovulatory levels of E2, causing a shift from peptidergic to glutamatergic transmission that drives the GnRH surge through enhanced glutamate neurotransmission.