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    1. Computational and Systems Biology
    2. Developmental Biology

    A quantitative modelling approach to zebrafish pigment pattern formation

    Jennifer P Owen, Robert N Kelsh, Christian A Yates
    A mathematical modelling approach to understanding zebrafish stripe pattern formation exemplifies a biological rule-set sufficient to generate wild-type and a diverse range of mutant patterns.
    1. Physics of Living Systems

    Mitigating memory effects during undulatory locomotion on hysteretic materials

    Perrin E Schiebel, Henry C Astley ... Daniel I Goldman
    Undulatory animals moving on the surface must manage material memory by either having a slender anatomy that facilitates avoiding previously remodeled substrate, or using waveshapes that effectively utilize the memory.
    1. Physics of Living Systems

    Theory for the optimal detection of time-varying signals in cellular sensing systems

    Giulia Malaguti, Pieter Rein ten Wolde
    A theory is presented for the optimal design of cellular sensing systems that maximizes the sensing precision given resource constraints.
    1. Cancer Biology
    2. Computational and Systems Biology

    Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

    Rolando Ruiz-Vega, Chi-Fen Chen ... Arthur D Lander
    Spontaneous growth arrest of transformed melanocytes (resulting in benign “moles”) does not result from cell-autonomous oncogene-induced senescence, but can be explained by collective mechanisms used in normal tissue size control.
    1. Developmental Biology
    2. Plant Biology

    Generation of shape complexity through tissue conflict resolution

    Alexandra B Rebocho, Paul Southam ... Enrico Coen
    Genetic modulation in patterns of tissue conflict play a major role in the development and evolution of shape diversity.
    1. Neuroscience
    2. Physics of Living Systems

    Mathematical relationships between spinal motoneuron properties

    Arnault H Caillet, Andrew TM Phillips ... Luca Modenese
    Validated mathematical relationships between motoneuron morphometric and electrophysiological properties are provided as a tool for neuroscientists and modellers to generate hypotheses for experimental studies investigating currently unreported relationships and build virtual motoneuron profiles with consistent properties for modelling purposes.
    1. Biochemistry and Chemical Biology

    Repression of ferritin light chain translation by human eIF3

    Mia C Pulos-Holmes, Daniel N Srole ... Jamie H Cate
    Human ferritin light chain (FTL) mRNA translation is regulated via its 5'-untranslated region (5'-UTR) by three mechanisms: RNA folding, iron response protein binding, and eukaryotic translation initiation factor eIF3 binding.
    1. Developmental Biology
    2. Evolutionary Biology

    Secondary ossification center induces and protects growth plate structure

    Meng Xie, Pavel Gol'din ... Andrei S Chagin
    The principle underlying the appearance of the growth plate, an organ responsible for longitudinal growth, has implications for various cartilage pathologies including growth abnormalities in children, trauma and osteoarthritis.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Repeated outbreaks drive the evolution of bacteriophage communication

    Hilje M Doekes, Glenn A Mulder, Rutger Hermsen
    Mathematical modelling suggests that the evolution of communication between bacterial viruses requires repeated outbreak events, and the model then predicts typical communication strategies.
    1. Microbiology and Infectious Disease

    Fitness advantage of Bacteroides thetaiotaomicron capsular polysaccharide in the mouse gut depends on the resident microbiota

    Daniel Hoces, Giorgia Greter ... Emma Slack
    Neutral tagging and detailed analysis of bacterial growth kinetics can quantify the mechanisms of colonization resistance in differently colonized animals.