1,877 results found
    1. Neuroscience

    Nucleus accumbens dopamine tracks aversive stimulus duration and prediction but not value or prediction error

    Jessica N Goedhoop, Bastijn JG van den Boom ... Ingo Willuhn
    The extracellular concentration of dopamine in the nucleus accumbens core is progressively diminished by white noise, an underutilized, easy-to-titrate aversive stimulus, but is unaffected by white-noise intensity, context valence, and associated probabilistic contingencies.
    1. Developmental Biology
    2. Neuroscience

    Semaphorin7A patterns neural circuitry in the lateral line of the zebrafish

    Agnik Dasgupta, Caleb C Reagor ... AJ Hudspeth
    Semaphorin7A sculpts the collective arbor architecture of the lateral line nerve and facilitates neural contacts with the hair cells for synaptogenesis during neuromast development in the zebrafish.
    1. Cell Biology
    2. Developmental Biology

    Anisotropic organization of circumferential actomyosin characterizes hematopoietic stem cells emergence in the zebrafish

    Mylene Lancino, Sara Majello ... Anne Schmidt
    Emergence of hematopoietic stem cells from an aortic component is a unique phenomenon of cell extrusion, with no equivalent in cell biology, and which is adapted to environmental constraints exerted by endothelial cells and hemodynamics forces.
    1. Neuroscience

    Functional links between sensory representations, choice activity, and sensorimotor associations in parietal cortex

    Ting-Yu Chang, Raymond Doudlah ... Ari Rosenberg
    The fidelity of 3D visual object representations, choice-related activity, and experience-dependent sensorimotor associations are functionally linked in the caudal intraparietal area.
    1. Neuroscience

    Complexity of frequency receptive fields predicts tonotopic variability across species

    Quentin Gaucher, Mariangela Panniello ... Kerry MM Walker
    The A1 of ferrets and mice show similar tonotopic organizations, with neurons preferring a single frequency being more precisely organized into a tonotopic map than multipeaked neurons.
    1. Biochemistry and Chemical Biology

    Hypertrophic cardiomyopathy mutations in the pliant and light chain-binding regions of the lever arm of human β-cardiac myosin have divergent effects on myosin function

    Makenna M Morck, Debanjan Bhowmik ... Kathleen M Ruppel
    Hypertrophic cardiomyopathy-causing mutations in the light chain-binding region of β-cardiac myosin's lever arm appear to disrupt myosin tail-based autoinhibition, while mutations in the pliant region of the lever arm reduce autoinhibition in the presence of actin and impact myosin’s powerstroke.
    1. Neuroscience

    A searchable image resource of Drosophila GAL4 driver expression patterns with single neuron resolution

    Geoffrey W Meissner, Aljoscha Nern ... FlyLight Project Team
    Single neuron images of Drosophila driver lines reveal neuron shape and are searchable, enabling comparisons to electron microscopy and prediction of intersectional neuron targeting strategies.
    1. Neuroscience
    2. Computational and Systems Biology

    The individuality of shape asymmetries of the human cerebral cortex

    Yu-Chi Chen, Aurina Arnatkevičiūtė ... Kevin M Aquino
    Asymmetries between the shape of the left and right human cortex are highly unique to individuals, akin to a neuroanatomical fingerprint, related to cognitive function, and primarily driven by person-specific environmental influences.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Circadian RNA expression elicited by 3’-UTR IRAlu-paraspeckle associated elements

    Manon Torres, Denis Becquet ... Anne-Marie François-Bellan
    Circadian gene expression can be driven by a post-transcriptional mechanism involving circadian mRNA nuclear retention by paraspeckle nuclear bodies.
    1. Cell Biology
    2. Developmental Biology

    Adult mouse fibroblasts retain organ-specific transcriptomic identity

    Elvira Forte, Mirana Ramialison ... Milena B Furtado
    Adult mouse fibroblasts maintain an embryonic gene expression signature, inherited from their organ of origin, that is important for organ homeostasis and fibrosis, and may assist in targeting fibrotic diseases in an organ-specific manner.

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