370 results found
    1. Epidemiology and Global Health

    Mathematical modeling of the West Africa Ebola epidemic

    Jean-Paul Chretien et al.
    A review of mathematical models applied to the West Africa Ebola epidemic suggests ways to improve the use of mathematical modeling in responding to public health emergencies.
    1. Immunology
    2. Microbiology and Infectious Disease

    Rapid localized spread and immunologic containment define Herpes simplex virus-2 reactivation in the human genital tract

    Joshua T Schiffer et al.
    A combination of detailed sampling and mathematical modeling suggests that the response of immune cells to reactivation of herpes simplex virus 2 is extremely rapid and effective within microscopic areas of genital skin.
    1. Cell Biology
    2. Computational and Systems Biology

    Dynamic NF-κB and E2F interactions control the priority and timing of inflammatory signalling and cell proliferation

    John M Ankers et al.
    Cell imaging and mathematical modelling show reciprocal cross-regulation between inflammatory signalling and cell cycle timing, which is mediated through functional interactions between NF-B and E2F proteins.
    1. Computational and Systems Biology
    2. Ecology

    Lotka-Volterra pairwise modeling fails to capture diverse pairwise microbial interactions

    Babak Momeni et al.
    With mathematical modeling being an important source of insight for microbial communities, we may need to move beyond commonly-used pairwise models that do not capture microbial interactions.
    1. Computational and Systems Biology
    2. Immunology

    T-cell Immunology: The maths of memory

    Jose Borghans, Ruy M Ribeiro
    Mathematical modeling reveals that long-term immunological memory is maintained in a manner that is even more dynamic than previously thought.
    Insight
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  1. Research: Theory, models and biology

    Wenying Shou et al.
    Theoretical ideas have a rich history in many areas of biology, and new theories and mathematical models have much to offer in the future.
    Editorial
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    1. Biophysics and Structural Biology
    2. Neuroscience

    Additive effects on the energy barrier for synaptic vesicle fusion cause supralinear effects on the vesicle fusion rate

    Sebastiaan Schotten et al.
    Independent osmotic, genetic and biochemical perturbations modulate neurotransmitter release in a multiplicative manner.
    1. Neuroscience

    Calcium dynamics regulating the timing of decision-making in C. elegans

    Yuki Tanimoto et al.
    A series of quantitative behavioural and opto-physiological analyses using a novel robot microscope system reveals that C. elegans computes the time-differential and time-integral of sensory information for decision-making during olfactory navigation.
    1. Computational and Systems Biology
    2. Developmental Biology and Stem Cells

    Reconstructing the in vivo dynamics of hematopoietic stem cells from telomere length distributions

    Benjamin Werner et al.
    Telomere length distributions can be used to infer important properties of stem cell proliferation.

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