6,826 results found
    1. Stem Cells and Regenerative Medicine

    Long-term live imaging of the Drosophila adult midgut reveals real-time dynamics of division, differentiation and loss

    Judy Lisette Martin et al.
    A new platform for imaging live Drosophila adults yields vivid movies of the midgut over prolonged time scales, opening the door to the real-time study of organ renewal dynamics in a near-native context.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Length-dependent flagellar growth of Vibrio alginolyticus revealed by real time fluorescent imaging

    Meiting Chen et al.
    The length-dependent growth rate of bacterial flagellar filament is determined by the flagellin loading speed, loading strength and its diffusion process.
    1. Cell Biology
    2. Developmental Biology

    CytoCensus, mapping cell identity and division in tissues and organs using machine learning

    Martin Hailstone et al.
    Easy-to-use image analysis software enables single cell quantitation of cell types and division rates in complex 3D tissues including living Drosophila brains, mouse embryos and Zebrafish organoids.
    1. Structural Biology and Molecular Biophysics

    Helix breaking transition in the S4 of HCN channel is critical for hyperpolarization-dependent gating

    Marina A Kasimova et al.
    The gating polarity of a voltage-gated ion channel is primarily determined by turn propensity of residues at a critical position in the middle of the S4 voltage-sensing helix.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM structure of the ATP-sensitive potassium channel illuminates mechanisms of assembly and gating

    Gregory M Martin et al.
    Single-particle cryo-electron microscopy reveals the first subnanometer structure of ATP-sensitive potassium (KATP) channels, which provides insight into the structural mechanisms of channel assembly and gating.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Homing Genetic Elements: Mobile DNAs and switching mating types in yeast

    Laura N Rusche
    The gene that allows budding yeast cells to switch their mating type evolved from a newly discovered family of genes named weird HO.
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    1. Neuroscience

    Imaging: The many facets of brain aging

    Lars Nyberg, Anders Wåhlin
    Applying big-data analytic techniques to brain images from 18,707 individuals is shedding light on the influence of aging on the brain.
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  1. Cutting Edge: A network approach to mixing delegates at meetings

    Federico Vaggi et al.
    A network-based ‘speed dating’ approach can promote interactions between delegates at scientific meetings.
    1. Cell Biology
    2. Developmental Biology

    Microscopy: Live imaging looks deeper

    Tanner C Fadero, Paul S Maddox
    Iodixanol provides an easy and affordable solution to a problem that has limited resolution and brightness when imaging living samples.
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    1. Cell Biology

    Spatiotemporal regulation of autophagy during Caenorhabditis elegans aging

    Jessica T Chang et al.
    Autophagic flux assays in the nematode Caenorhabditis elegans suggest that autophagy decreases during normal aging, whereas long-lived daf-2 and glp-1 mutants maintain autophagic capacity in distinct spatiotemporal-specific manners to extend lifespan.

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