8,509 results found
    1. Computational and Systems Biology

    Environmental fluctuations reshape an unexpected diversity-disturbance relationship in a microbial community

    Christopher P Mancuso et al.
    Laboratory experiments using a microbial community and mathematical modeling reveal how environmental disturbances can predictably alter the diversity and composition of an ecosystem.
    1. Biochemistry and Chemical Biology

    A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation

    Gajanan S Patil et al.
    The structural basis of how an enzyme differentiates chemically identical molecules unlike its homolog to channel fatty acids towards secondary metabolism is elucidated.
    1. Neuroscience

    Dendritic osmosensors modulate activity-induced calcium influx in oxytocinergic magnocellular neurons of the mouse PVN

    Wanhui Sheng et al.
    Activity-induced dendritic calcium influx in oxytocinergic magnocellular neurons can be robustly modulated by a highly diverse set of stimuli acting on distinct types of ion channels expressed along the dendritic membrane.
    1. Neuroscience

    Dorsal premammillary projection to periaqueductal gray controls escape vigor from innate and conditioned threats

    Weisheng Wang et al.
    Activity in the hypothalamic dorsal premammillary nucleus predicts future escape from threat, represents escape velocity, and controls escape velocity via a projection to the brainstem.
    1. Neuroscience

    A unified platform to manage, share, and archive morphological and functional data in insect neuroscience

    Stanley Heinze et al.
    The InsectBrain Database is a novel, freely available software tool designed to accelerate research in the field of insect neuroscience and to improve implementation of open data concepts.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa

    Gukui Chen et al.
    The diguanylate cyclase activity of SiaD is activated by its binding partner SiaC thourgh a dynamic mechanism of promoting the formation of active SiaD dimers.
    1. Ecology
    2. Epidemiology and Global Health

    Physiology and ecology combine to determine host and vector importance for Ross River virus

    Morgan P Kain et al.
    The role host and vector species play in pathogen transmission cycles is best quantified by integrating species' physiological and ecological competence.
    1. Epidemiology and Global Health
    2. Genetics and Genomics

    A proteome-wide genetic investigation identifies several SARS-CoV-2-exploited host targets of clinical relevance

    Mohd Anisul et al.
    Genetic integration of human protein abundance variation and COVID-19 susceptibility identifies proteins with potential causal roles in antiviral responses, coagulation, cytokine activation, and direct receptor interactions with SARS-CoV-2.
    1. Ecology

    Widespread variation in heat tolerance and symbiont load are associated with growth tradeoffs in the coral Acropora hyacinthus in Palau

    Brendan Cornwell et al.
    Bleaching-resistant corals are widespread across Palau and concentrated in warmer regions, but this trait is associated with decreased growth which could lead to reduced fitness if it is the only priority of conservation efforts.
    1. Genetics and Genomics

    The dual role of amyloid-β-sheet sequences in the cell surface properties of FLO11-encoded flocculins in Saccharomyces cerevisiae

    Clara Bouyx et al.
    The role of amyloid-β-aggregation sequence and of the various domains in the physiological function of the FLO11-encoded adhesin in the yeast Saccharomyces cerevisiae are disclosed in this report.

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