Christopher M Ciarleglio, Arseny S Khakhalin ... Carlos D Aizenman
The diversity of electrophysiological phenotypes of neurons in a functional network increases over development, but can be modulated, and even reduced by sensory experience; allowing them to adapt to a changing and growing brain.
Integrating human embryonic transcriptomes from 15 sites during organogenesis identifies novel expression signatures linked to congenital disorders and a new programme of non-coding gene expression.
Janelle MP Pakan, Scott C Lowe ... Nathalie L Rochefort
The three main types of inhibitory neurons in mouse primary visual cortex respond differently to locomotion in darkness and during visual stimulation, revealing context-dependent responses to changes in behavioral state.
A novel statistical algorithm for mining high-dimensional spike train (count) data for significant spatio-temporal patterns reveals new insights into task and brain area dependent functional organization of neural activity.
David GT Barrett, Sophie Denève, Christian K Machens
Spiking networks compensate the loss of neurons instantaneously, when restoration of excitatory/inhibitory balance becomes equivalent to restoration of functionality.
New experiments and theory reveal how the ability to see image details depends upon photoreceptor function and eye movements, and how fruit flies (Drosophila) see spatial details beyond the optical limit of their compound eyes.
Establishment of two-photon imaging with a 1100-nm laser, which underfills the objective's back aperture, detects activity of multiple neurons in the prelimbic area and hippocampal CA1 region of the intact mouse brain.