Biochemical and cell biological data suggest a model of nascent integrin adhesion complex formation based on synergistic phase separation of pathways surrounding the focal adhesion kinase (FAK) and the adaptor protein p130Cas.

Functional molecular analysis of cytokinesis in Caenorhabditis elegans four-cell embryos reveals cell-type-specific variation in the fundamental dependence on a robust f-actin cytoskeleton for successful cell division, mediated by both cell-intrinsic and -extrinsic pathways.

The fact that sexual activity/reproduction doubles the lifespan of certain rodent species is most likely linked to critical changes in the regulation of the hypothalamic–pituitary–adrenal stress axis.

A previously unknown calcium channel in human placental trophoblasts provides a calcium source for activating TMEM16F lipid scramblase that flip-flops phospholipids on cell surface, demonstrating a physiological mechanism that helps to understand how lipid dynamics regulates cell fusion.

SINE RNAs are implicated in amyloid beta molecular pathology in hippocampus.

The dimer destabilizers cause a dimer-to-monomer equilibrium shift favoring the human thymidylate synthase monomer more degradable by the proteasome, thus breaking the long-standing link between inhibition and enhanced expression of the protein to fight cancer drug resistance.

The allele-specific gene-editing drug is expected to make RHO-T17M-associated retinitis pigmentosa therapy a reality.

The sense of smell of female hawkmoths has evolved to find the intense odor of floral nectar sources as well as inconspicuous scents of oviposition sites within a complex olfactory landscape.

RNA-binding proteins use both translational activation and repression of key molecular determinants to post-mitotically sculpt the identity and connectivity of developing mouse neocortex in an area-specific manner.

Cryo-EM reveals the regulation of RUVBL1 and RUVBL2 AAA-ATPases by DHX34, a helicase involved in nonsense-mediated mRNA decay (NMD), and suggests mechanisms for how RUVBL1 and RUVBL2 function in NMD.