A mouse model of endometriosis reveals that moderate doses of Δ9-tetrahydrocannabinol produce clear regression of ectopic endometrial growths, pronounced alleviation of pelvic pain and unexpected memory improvements.
Pleasant touch perception in humans is unaffected by spinothalamic disruption indicating integrated spinal processing of hedonic and discriminative tactile inputs rather than privileged C-tactile-lamina I-spinothalamic projections.
A signal amplifier network that transmits mechanical pain is delineated through characterising an excitatory interneuron population in the spinal cord dorsal horn and defining the postsynaptic populations they regulate.
The flow of somatosensory information through the spinal dorsal horn is regulated by synaptic inhibition, which acts upon excitatory and inhibitory interneurons, but the former are especially prone to disinhibition.
The mechanosensitive potassium channel TRAAK is localized to nodes of Ranvier is mammalian axons where it hyperpolarizes the resting potential and may contribute to mechanical repolarization of neurons.